Table 3

Association of baseline factors with 5-year change rate of TISA500 in dark condition

Baseline variableModel 1
coefficient (95% CI)
P valueModel 2
coefficient (95% CI)*
P value
Age, year0.0226 (−0.0139 to 0.059)0.2250.0175 (−0.0127 to 0.0479)0.256
Gender (M/F)−0.1572 (−0.523 to 0.209)0.400−0.355 (-0.8727 to 0.1626)0.179
Weight, kg0.0077 (−0.0104 to 0.0260)0.4040.0071 (−0.0130 to 0.0273)0.488
Height, cm−0.0085 (−0.0215 to 0.0044)0.197−0.0343 (−0.0613 to −0.0081) 0.005
SBP, mm Hg0.00021 (−0.0040 to 0.0044)0.922−0.0026 (−0.0134 to 0.00610)0.467
DBP, mm Hg−0.0038 (−0.0151 to 0.0074)0.499−0.0016 (−0.0171 to 0.0147)0.811
SE, dioptre−0.0133 (−0.0557 to 0.0291)0.538−0.0607 (−0.1192 to 0.0158)0.151
AL, mm−0.0077 (−0.0127 to -0.0027) 0.003 0.0218 (−0.0739 to 0.1230)0.634
ACD, mm−0.0124 (−0.3141 to 0.2893)0.936−0.2211 (−1.234 to 0.7863)0.688
LT, mm−0.0059 (−0.0089 to −0.0028) 0.011 0.0090 (−0.0111 to 0.0296)0.120
TISA500, mm2 −6.2306 (−11.0521 to −1.4090) < 0.001 −26.838 (−47.262 to −20.203) 0.008
ARA, mm2 −2.3040 (−3.9662 to −0.6419) 0.007 6.7115 (−3.6145 to 16.380)0.066
IT750, mm−0.4571 (−1.3943 to 0.4801)0.339−3.1758 (−4.989 to 0.5221) 0.003
Iarea, mm2 0.1688 (−0.1140 to 0.3451)0.0670.7658 (−0.3135 to 1.6066)0.094
ACW, mm0.7760 (0.2823 to 1.2697) 0.002 0.0221 (−0.5721 to 0.7389)0.931
ACA, mm2 0.0447 (−0.0312 to 0.1206)0.2490.1318 (0.0113 to 0.2838) 0.023
LV, μm0.0002 (−0.0004 to 0.0009)0.4550.0001 (−0.00101 to 0.0012)0.786
PD, mm−0.0768 (−0.2502 to 0.0966)0.3860.0304 (−0.3108 to 0.3339)0.847
ΔARA, mm2 1.3023 (−0.0599 to 2.6646)0.061−2.1270 (−30.0325 to −3.8854)0.272
ΔIT750, mm2 0.1777 (−0.4321 to 0.7876)0.568−0.9749 (−1.302 to 11.9384)0.266
ΔIarea, mm2 −0.1074 (−0.2874 to 0.0727)0.2430.1311 (−0.66559 to 1.2264)0.753
ΔACW, mm−0.9413 (−1.6071 to −0.2755) 0.006 −0.2284 (−1.236 to 1.10341)0.643
ΔACA, mm2 0.4067 (−0.3564 to 1.169)0.2960.4083 (−0.1823 to 0.018)0.232
ΔLV,μm−0.0032 (−0.0060 to 0.0004) 0.027 −0.0024 (−0.0060 to −0.0015)0.224
ΔPD, mm0.0888 (−0.0753 to 0.2731)0.2660.0783 (−0.2378 to 0.4040)0.662
  • TISA500 change was defined as TISA500 in 2013 minus TISA500 in 2008.

  • Model 1 is a univariate regression analysis; model 2 is a multiple regression analysis.

  • Bold indicates statistical significance.

  • *Adjusted for age, gender, weight, height, SBP, DBP, SE, AL, ACD, LT, TISA500, ARA, IT750, larea, ACW, LV, PD, ΔARA, ΔIT750, ΔIarea, ΔACW, ΔACA, ΔLV, ΔPD.

  • Δ, light-to-dark changes (dark minus light); ACA, anterior chamber area; ACD, anterior chamber depth; ACW, anterior chamber width; AL, axial length; ARA, angle recess area; DBP, diastolic blood pressure; ΔIT750, iris thickness at 750 µm; Iarea, iris area; LT, lens thickness; LV, lens vault; PD, pupil diameter; SBP, systolic blood pressure; SE, spherical equivalent; TISA500, trabecular iris space area at 500 µm.