Table 1

Summary of studies included in the systematic review, including description of study design, number of studies, number of patients, source of funding and length of follow-up

Study design
RCTObservational studyCase study
Number of included studies n (%)99 (46.3)87 (40.6)28 (13.1)
Number of patient n (%)28 232 (33.8)55 250 (66.1)53 (0.1)
Source of funding n (%)
 None5 (0.05)7 (0.08)5 (0.18)
 Industry54 (0.55)41 (0.47)0
 Public01 (0.01)4 (0.14)
 Unspecified40 (0.40)38 (0.44)19 (0.68)
Length of follow-up in months
Mean (SD)4.85 (5.34)8.26 (11.58) 5.16 (4.28)
Range0.2–360.5–600.5–19
  • RCT, randomised controlled trial.