Comparison of RNFL thickness measured by two OCT systems, stratified by glaucoma status
| Region | SS-OCT | SD-OCT | Mean difference (95% CI)* | ICC (95% CI)† | |||
| Mean (SD) | COV | Mean (SD) | COV | ||||
| Total (n=94, n=57) | Inferior | 114.1 (24.3) | 4.7 | 113.0 (22.4) | 5.05 | 1.1 (−0.7 to 3.0) p=0.231 | 0.92 (0.88 to 0.95) |
| Superior | 106.9 (22.3) | 4.79 | 107.0 (20.3) | 5.26 | −0.1 (−1.9 to 1.6) p=0.868 | 0.91 (0.87 to 0.94) | |
| Nasal | 69.7 (11.5) | 6.04 | 66.3 (9.3) | 7.12 |
3.4 (2.0 to 4.8) p<0.001 | 0.73 (0.64 to 0.82) | |
| Temporal | 75.6 (13.7) | 5.52 | 67.9 (12.3) | 5.51 |
7.7 (6.6 to 8.8) p<0.001 | 0.79 (0.71 to 0.85) | |
| Global | 91.6 (13.5) | 6.78 | 88.6 (12.5) | 7.08 |
3.0 (2.1 to 3.9) p<0.001 | 0.91 (0.86to 0.94) | |
| Glaucoma (n=12, n=9) | Inferior | 77.8 (20.9) | 3.72 | 77.8 (21.0) | 3.7 | −0.0 (−4.6 to 4.6) p=0.995 | 0.95 (0.89 to 0.98) |
| Superior | 81.3 (23.8) | 3.42 | 80.6 (21.2) | 3.8 | 0.7 (−3.5 to 4.9) p=0.707 | 0.93 (0.78to 0.98) | |
| Nasal | 65.0 (13.9) | 4.68 | 63.5 (11.6) | 5.47 | 1.5 (−4.7 to 7.7) p=0.596 | 0.76 (0.41 to 0.92) | |
| Temporal | 63.7 (15.2) | 4.18 | 56.5 (13.7) | 4.13 |
7.2 (3.3 to 1
1.1) p=0.003 | 0.81 (0.65 to 0.92) | |
| Global | 71.9 (14.5) | 4.97 | 69.6 (13.6) | 5.13 |
2.3 (0.0 to 4.7) p=0.050 | 0.95 (0.89 to 0.98) | |
| OHT (n=8, n=5) | Inferior | 122.8 (22.1) | 5.56 | 119.1 (18.2) | 6.54 | 3.7 (−4.6 to 11.9) p=0.285 | 0.88 (0.13 to 0.92) |
| Superior | 109.0 (13.2) | 8.28 | 108.3 (16.4) | 6.6 | 0.7 (−6.8 to 8.2) p=0.815 | 0.88 (0.64 to 0.96) | |
| Nasal | 70.4 (9.6) | 7.32 | 65.8 (9.9) | 6.67 | 4.6 (−7.1 to 16.3) p=0.338 | 0.31 (0.00 to 0.61) | |
| Temporal | 79.1 (22.3) | 3.55 | 73.2 (19.0) | 3.85 |
5.9 (1.3 to 10.6) p=0.024 | 0.94 (0.82 to 0.98) | |
| Global | 95.3 (12.3) | 7.76 | 91.6 (10.0) | 9.12 | 3.7 (−1.0 to 8.4) p=0.092 | 0.82 (0.67 to 0.92) | |
| Normal (n=74, n=45) | Inferior | 119.1 (19.7) | 6.03 | 118.1 (17.5) | 6.74 | 1.0 (−1.2 to 3.2) p=0.354 | 0.87 (0.81 to 0.92) |
| Superior | 110.8 (20.2) | 5.48 | 111.2 (17.3) | 6.41 | −0.4 (−2.5 to 1.8) p=0.726 | 0.88 (0.83 to 0.91) | |
| Nasal | 70.4 (11.3) | 6.23 | 66.9 (8.9) | 7.51 |
3.6 (2.2 to 5.0) p<0.001 | 0.76 (0.68 to 0.84) | |
| Temporal | 77.2 (11.4) | 6.79 | 69.2 (10.2) | 6.77 |
8.0 (6.7 to 9.2) p<0.001 | 0.71 (0.61 to 0.79) | |
| Global | 94.4 (10.7) | 8.86 | 91.3 (9.7) | 9.41 |
3.1 (2.0 to 4.1) p<0.001 | 0.86 (0.79 to 0.90) | |
*The sandwich estimator that allows for clustering for patient was used to calculate SEs.
†Non-parametric cluster-resampled bootstrapping was used to derive the sampling distribution of ICC estimates.
COV, coefficient of variance; ICC, intraclass correlation coefficient; OCT, optical coherence tomography; SS, swept-source.