Table 2

Summary of antibiotic susceptibility of infectious keratitis in Nottingham, UK, between 2007–2013 and 2014–2019

Organisms2007–20192007–20132014–2019P value*
n (%)n (%)n (%)
Gram-positive
 Penicillin†260/283 (91.9)136/141 (96.5)124/142 (87.3)0.005
 Cefuroxime25/25 (100.0)17/17 (100.0)8/8 (100.0)1.0
 Gentamicin177/186 (95.2)97/101 (96.0)80/85 (94.1)0.73
 Ciprofloxacin164/182 (90.1)92/100 (92.0)72/82 (87.8)0.35
 Levofloxacin41/41 (100.0)16/16 (100.0)25/25 (100.0)1.0
Gram-negative
 Penicillin†36/80 (45.0)18/38 (47.4)18/52 (34.6)0.22
 Cefuroxime65/80 (81.3)30/38 (78.9)35/42 (83.3)0.62
 Amikacin172/174 (98.9)91/92 (98.9)81/82 (98.8)1.0
 Gentamicin174/177 (98.3)93/94 (98.9)81/83 (97.6)0.6
 Ciprofloxacin175/179 (97.8)92/94 (97.9)83/85 (97.6)1.0
 Levofloxacin53/53 (100.0)16/16 (100.0)37/37 (100.0)1.0
  • *Chi-square or Fisher’s exact test (if any variable was <5) was performed to determine the significant difference between the two time periods. Significant p value is underlined.

  • †Penicillin group includes penicillin, amoxicillin and flucloxacillin.