Table 1

Summary of microbiological profiles of infectious keratitis in Nottingham, UK, between 2007–2013 and 2014–2019

Organisms2007–20192007–20132014–2019P value*
n=572; n (%)n=282; n (%)n=290; n (%)
Gram-positive308 (53.8)153 (54.3)155 (53.4)0.53
S. aureus91 (15.9)49 (17.4)42 (14.5)0.34
 CoNS75 (13.1)39 (13.8)36 (12.4)0.64
Streptococci spp77 (13.5)37 (13.1)40 (13.8)0.74
 Bacilli63 (11.0)28 (9.9)35 (12.1)0.35
 Others†2 (0.3)0 (0.0)2 (0.7)0.5
Gram-negative223 (39.0)108 (38.3)115 (39.7)0.74
P. aeruginosa135 (23.6)67 (23.8)68 (23.4)0.66
Moraxella spp37 (6.5)8 (2.8)29 (10.0)<0.001
Klebsiella spp11 (1.9)10 (3.5)1 (0.3)0.004
 Others‡40 (7.0)23 (8.2)17 (5.9)0.21
Fungi17 (3.0)10 (3.5)7 (2.4)0.43
 Yeast10 (1.7)6 (2.1)4 (1.4)0.91
 Filamentous7 (1.2)4 (1.4)3 (1.0)0.91
Acanthamoeba24 (4.2)11 (3.9)13 (4.5)0.72
  • *Chi-square or Fisher’s exact test (if any variable was <5) was used to detect any significant changing trend of the microbiological profiles between 2017–2013 and 2014–2019. The analysis was performed at two levels; the first level evaluated the changes among Gram-positive and Gram-negative organisms, fungi and acanthamoeba; and the second level examined the changes of the subtypes of the organisms within the four groups. Significant p values (<0.05) are underlined.

  • †Others include Enterococci spp.

  • ‡Others Include Achromobacter spp, Acinetobacter spp, Citrobacter koseri, Enterobacter spp, Kingella spp, Serratia marcescens, Haaemophilus spp, Proteus spp, Neisseria spp and Stenotrophomonas maltophilia.

  • CoNS, coagulase-negative staphylococcus.