Summary of the microbiological profiles and antibiotic susceptibility of infectious keratitis in the UK between 2010 and 2019 (based on year of publication)
| Year | Authors | Study period | Region | Total CS | Culture positivity (%) | Microbiological profiles* | Antibiotic susceptibility (%)† | |||
| PEN | CEF | AMG | FQ | |||||||
| 2011 | Orlans et al13 | 1999–2009 | Oxford | 467 | 54.0 | Pseudomonas spp (28.5%); CoNS (25.8%); S. aureus (12.4%) | 50.4 (P) | 80.9 (P); 8.7 (N) | 87.2 (P); 100 (N) | 85.4 (P); 99.0 (N) |
| 2017 | Tan et al14 | 2004–2015 | Manchester | 4229 | 32.6 | CoNS (24.4%); S. aureus (15.1%); Streptococci (13.3%) | – | 86.6 (P); 61.4 (N); | 88.8 (P); 96.5 (N) | 83.1 (P); 90.8 (N) |
| 2018 | Ting et al9 | 2008–2017 | Sunderland | 914 | 44.5 | CoNS (25.9%); S. aureus (13.6%); Streptococci (12.1%) | – | – | – | – |
| 2019 | Tavassoli et al15 | 2006–2017 | Bristol | 2614 | 38.1 | CoNS (36.0%); Pseudomonas spp (15.8%); Streptococci (7.0%) | 95.0–100 (P); 31.0 (N) | – | 100 (P); 97.0–100 (N) | 91.0–100 (P); 97.0–100 (N) |
| 2020 | Ting et al9 (current study) | 2007–2019 | Nottingham | 1333 | 37.7 | Pseudomonas spp (23.6%); S. aureus (15.9%); Streptococci 13.5%) | 91.9 (P); 45.0 (N) | 100 (P); 81.3 (N) | 95.2 (P); 98.3–98.9 (N) | 90.1–100 (P); 97.8–100 (N) |
*The three most common microorganisms isolated in the study.
†P = Gram-positive bacteria; n=Gram-negative bacteria.
AMG, aminoglycosides (include gentamicin and amikacin); CEF, cefuroxime; CoNS, coagulase-negative staphylococci; CS, corneal scrapes; FQ, fluoroquinolones (include ciprofloxacin, ofloxacin and levofloxacin); PEN, penicillin.