Table 1

Summary of corneal transplantation techniques for the treatment of endothelial diseases and their reported outcomes (selected studies)

Corneal endothelial transplantation techniqueYear introducedVisual acuities
(≤ 12 months)
Graft detachment/rebubbling ratesImmune rejection rate (%)Percentage endothelial cell loss at 1 year/5 yearsGraft survival rates
(5 year)
IOP elevation
Penetrating keratoplasty19054.6–19% ≥20/2523 47 NA5–17%23 204 205 35.8–45%23 36/61–7%22 206 44–90%22 23 207 208 12–60%23 209 212
Modified posterior lamellar keratoplasty (PLK)/deep lamellar endothelial keratoplasty (DLEK)19980–28.6% ≥20/2532 34 37 8.8%36 4.4%36 26–43%36 213/62%37 72%37 13.2%31
Descemet’s stripping endothelial keratoplasty (DSEK)/Descemet’s stripping automated endothelial keratoplasty (DSAEK)200415.3–72% ≥20/2523 47 60 0.7–15.6%23 36 7.3–12%23 216 15–36%23 36 54 60 217/47–55%22 218 62–96%22 23 123 218 220

1.7–37%23 212 216 221 223
Descemet’s membrane endothelial keratoplasty (DMEK)200632–85% ≥20/2523 224 0.2–74%23 77 224–226 0.7–5%23 205 218 227 19–40%23 227 228/39–48%79 218 93–99%23 218 226 229 2.8–12%23 230 231
  • IOP, intraocular pressure.