Mean values of the average 360° RNFL thickness and the RNFL thickness in the superior, nasal, inferior and temporal quadrants in healthy controls and patients with LHON at different disease progressions
| Group | Group control | Within 3 months (1st group) | 3–6 months (2nd group) | 6–9 months (3rd group) | 9–12 months (4th group) | 12–24 months (5th group) | 24–60 months (6th group) | >60 months (7th group) |
|---|---|---|---|---|---|---|---|---|
| RNFL average thickness (µm) | 103.10±9.11 | 109.92±27.39 | 84.77±32.61* | 64.30±21.03* | 51.36±13.77* | 50.16±16.54* | 39.83±10.31* | 44.10±14.02* |
| RNFL S thickness (µm) | 132.79±12.91 | 148.92±36.52 | 116.08±41.24 | 92.48±34.08* | 69.30±22.65* | 71.12±27.61* | 50.13±17.36*† | 61.90±25.40* |
| RNFL N thickness (µm) | 57.48±8.63 | 72.50±15.61* | 56.08±19.33 | 47.33±20.78 | 37.61±13.73* | 35.51±16.63* | 28.26±15.80* | 28.10±16.14* |
| RNFL I thickness (µm) | 134.02±20.96 | 147.92±40.91 | 118.31±48.47 | 80.04±29.32* | 69.97±21.37* | 63.37±21.72* | 49.74±13.13* | 56.71±17.50* |
| RNFL T thickness (µm) | 87.67±14.78 | 69.33±30.23* | 48.77±40.22* | 37.19±13.44* | 28.76±6.26* | 33.57±8.66* | 30.89±9.33* | 29.51±6.96* |
*P<0.05 when compared with healthy controls.
†P<0.05 when 6th group and 7th group were compared with 5th group, disease duration 12–24 months.
Data are shown as mean±SD. Values were compared by one-way analysis of covariance, followed by Bonferroni posthoc test. Sex and age were used as covariates in the analysis.
Group control, healthy control; I, inferior; LHON, Leber’s hereditary optic neuropathy; N, nasal; RNFL, retinal nerve fibre layer; S, superior; T, temporal; 1st group, disease duration ≤3 months; 2nd group, disease duration 3–6 months; 3rd group, disease duration 6–9 months; 4th group, disease duration 9–12 months; 5th group, disease duration 12–24 months; 6th group, disease duration 24–60 months; 7th group, disease duration >60 months.