Mean and SD of change in ocular comfort and tear film characteristics after 28 days of treatment (28 days minus baseline)
| Formulated eye drop (n=21) | Control eye drop (n=21) | P value | |
| Inferior LLT (nm) | −5.1±22.2 | −3.2±21.8 | 0.65 |
| TER (gm−2h) | −10.8±16.7 | 0.7±10.8 | 0.014 |
| TBUT (s) | 2.0±3.0 | 0.0±3.1 | 0.055 |
| Corneal staining (0–4) | −0.2±0.6 | 0.0±0.5 | 0.64 |
| OSDI (0–100) | −19.6±10.9 | −10.7±7.1 | 0.005 |
| Symptoms (0–100) | |||
| Burning/stinging | |||
| Grittiness/foreign | −10.7±23.2 | −8.9±18.6 | 0.90 |
| Body sensation | −20.8±20.4 | −15.0±17.9 | 0.30 |
| Dryness | −35.4±22.1 | −32.2±19.2 | 0.66 |
| Blurry vision | −13.6±22.5 | −20.6±29.8 | 0.14 |
| Overall discomfort | −14.7±15.1 | −10.7±17.5 | 0.30 |
LLT, lipid layer thickness; OSDI, Ocular Surface Disease Index; TBUT, tear break-up time; TER, tear evaporation rate.