Table 2

Genotype and allele frequencies of examined SNPs of TLR10 in PIU patients, PIU subgroups and healthy controls

CaseControl95% CIs
SNPsGroupGenotypeFrequenciesn(%)Frequenciesn(%)P valuePc valueORLower limitUpper limit
rs2101521PIU (n=992)GG12813.427218.12.19×10-03 NS0.700.560.88
GA45647.777051.1NSNS0.870.741.03
AA37238.946430.83.51×10-05 1.05×10-03 1.431.211.70
G71237.2131443.69.05×10-06 1.81×10-04 0.770.680.86
A120062.8169856.49.05×10-06 1.81×10-04 1.301.161.47
Cataract +group (n=430)GG5413.227218.12.14×10-02 NS0.690.510.95
GA20650.577051.1NSNS0.970.781.21
AA14836.346430.83.58×10-02 NS1.281.021.61
G31438.5131443.68.36×10-03 NS0.810.690.95
A50261.5169856.48.36×10-03 NS1.241.061.45
BK +group (n=331)GG3912.727218.12.20×10-02 NS0.660.460.94
GA14747.777051.1NSNS0.870.681.12
AA12239.646430.82.62×10-03 NS1.471.141.90
G22536.5131443.61.16×10-03 2.32×10-02 0.740.620.89
A39163.5169856.41.16×10-03 2.32×10-02 1.341.121.61
rs10004195PIU (n=992)AA29631.237024.31.48×10-04 4.44×10-03 1.421.181.70
AT45948.479752.3NSNS0.860.731.01
TT19320.435823.5NSNS0.830.681.02
A105155.4153750.45.61×10-04 1.12×10-02 1.221.091.37
T84544.6151349.65.61×10-04 1.12×10-02 0.820.730.92
Cataract +group (n=430)AA10926.837024.3NSNS1.150.891.47
AT21051.779752.3NSNS0.980.791.22
TT8721.435823.5NSNS0.890.681.16
A42852.7153750.4NSNS1.100.941.28
T38447.3151349.6NSNS0.910.781.06
BK +group (n=331)AA9430.737024.31.78×10-02 NS1.381.061.81
AT15249.779752.3NSNS0.900.711.15
TT6019.635823.5NSNS0.800.591.08
A34055.6153750.41.97×10-02 NS1.231.031.47
T27244.4151349.61.97×10-02 NS0.810.680.97
rs11725309PIU (n=992)TT27128.046730.4NSNS0.890.751.06
TC46948.579251.6NSNS0.880.751.04
CC22823.627718.08.02×10-04 2.41×10-02 1.401.151.71
T101152.2172656.26.07×10-03 NS0.850.760.96
C92547.8134643.86.07×10-03 NS1.171.051.32
Cataract +group (n=430)TT12730.546730.4NSNS1.000.791.27
TC20048.079251.6NSNS0.870.701.08
CC9021.627718.0NSNS1.250.961.63
T45454.4172656.2NSNS0.930.801.09
C38045.6134643.8NSNS1.070.921.25
BK +group (n=331)TT9028.546730.4NSNS0.910.701.19
TC14746.579251.6NSNS0.820.641.04
CC7925.027718.04.21×10-03 NS1.521.142.02
T32751.7172656.24.06×10-02 NS0.840.700.99
C30548.3134643.84.06×10-02 NS1.201.011.42
rs6841698PIU (n=992)AA24125.128318.61.10×10-04 3.29×10-03 1.471.211.78
AG43144.877851.02.53×10-03 NS0.780.660.92
GG29030.146430.4NSNS0.990.831.18
A91347.5134444.11.94×10-02 NS1.151.021.29
G101152.5170655.91.94×10-02 NS0.870.780.98
Cataract +group (n=430)AA14033.728318.63.16×10-11 9.48×10-10 2.231.762.84
AG17341.777851.07.49×10-04 2.25×10-02 0.690.550.85
GG10224.646430.42.01×10-02 NS0.750.580.96
A45354.6134444.17.24×10-08 1.45×10-06 1.531.311.78
G37745.4170655.97.24×10-08 1.45×10-06 0.660.560.76
BK +group (n=331)AA8828.228318.61.10×10-04 3.30×10-03 1.721.312.28
AG13342.677851.06.93×10-03 NS0.710.560.91
GG9129.246430.4NSNS0.940.721.23
A30949.5134444.11.26×10-02 NS1.251.051.48
G31550.5170655.91.26×10-02 NS0.800.680.95
  • +, having this feature; BK, band keratopathy; 95% CIs, 95% confidence intervals; HWE, Hardy–Weinberg equilibrium; NS, not significant; OR, odds ratio; PIU, paediatric idiopathic uveitis; SNPs, single nucleotide polymorphisms; TLR10, Toll-like receptors 10; Pc value, Bonferroni corrected p value.