Table 3

Change and change difference of accommodative amplitude and pupil diameter in three groups over 1 year*

VariablesMean (95% CI)
0.02% atropine0.01% atropineControl groupChange difference between 0.02% and 0.01% atropine
0–4 months change4–12 months change0–12 months change0–4 months change4–12 months change0–12 months change0–12 months change0–4 monthsP value4–12
months		P value0–12
months		P value
Accommodative amplitude−2.50†
(−3.01 to −1.99)		0.7
(0.4 to 1.0)		−1.9†
(−2.2 to −1.6)		−2.60†
(−3.11 to −2.09)		0.7
(0.3 to 1.1)		−1.8†
(−2.2 to −1.4)		−0.24
(−0.39 to −0.09)		0.11
(−0.08 to 0.29)		0.68−0.10
(−0.21 to 0.01)		0.49−0.10
(−0.21 to −0.01)		0.24
Pupil diameter0.87†
(0.66 to 0.98)		−0.10
(−0.15 to −0.05)		0.79†
(0.71 to 0.87)		0.77†
(0.64 to 0.90)		−0.08
(−0.01 to −0.15)		0.70†
(0.59 to 0.81)		0.12
(0.08 to 0.16)		0.10
(0.02 to 0.18)		0.55−0.02
(−0.01 to −0.03)		0.880.09
(0.03 to 0.15)		0.38

  • Change represents the slope of accommodative amplitude and pupil diameter over time for three groups. Change difference represents the difference in slope of accommodative amplitude and pupil diameter over time between the two groups.

  • *A generalised additive mixed model was used to estimate the longitudinal trend.

  • †Changes were significantly different.