Table 1

Allele and haplotype frequencies of HLA in cases and controls

ControlsGD without clinical eye phenotype groupProptosis groupMyogenic group
(2 n=822, %)(2 n=148, %)Pc*OR(2 n=164, %)Pc†OR(2 n=232, %)Pc‡OR
HLA Allele
B*38:0225 (3.0)4 (2.7)NS7 (4.3)NS20 (8.6)0.013.0
DRB1*16:0239 (4.7)17 (11.5)0.0482.627 (16.5)1.7×10−6 4.045 (19.4)1.4×10−11 4.8
DQA1*01:02163 (19.8)38 (25.7)NS42 (25.6)NS76 (32.8)5.9×10−4 2.0
DQB1*05:0221 (10.9)29 (19.6)1.1×10−16 9.336 (22.0)4.6×10−21 10.764 (27.6)7.2×10−34 14.5
HLA Haplotype
A*02:03-B*38:02-C*07:0213 (1.6)4 (2.7)NS0 (0.0)NS15 (6.5)0.024.3
DRB1*16:02-DQA1*01:02-DQB1*05:0239 (4.7)17 (11.5)NS27 (16.5)3.9×10−6 4.045 (19.4)3.2×10−11 4.8
DRB1*16:02-DQA1*01:02-DQB1*05:02-D PA1*02:02-DPB1*05:0123 (2.8)8 (5.4)NS17 (10.3)2×10−3 4.037 (15.9)7.7×10−12 6.6
A*02:03-B*38:02-C*07:02-DRB1*16:02-DQA1*01:02-DQB1*05:02-DPA1*02:02-DPB1*05:013 (0.4)2 (1.6)NS1 (0.1)NS11 (4.7)1.7×10−3 13.6
  • *Pc: GD without clinical eye phenotype group vs controls.

  • †Pc: proptosis group vs controls.

  • ‡Pc: myogenic group vs controls.

  • Only HLA alleles with corrected p values <0.05 are shown. The p value was calculated using χ2 test or Fisher’s exact test and corrected for the number of tests performed (Allele B: 63, DRB1: 40, DQA1: 18, DQB1:18; Haplotype A−B-C: 404, DRB1-DQA1-DQB1: 93, DRB1-DQA1-DQB1-DPA1-DPB1: 338, A−B-C-DRB1-DQA1-DQB1-DPA1-DPB1: 1143).

  • HLA, human leucocyte antigen; NS, not significant; OR, odds ratio; Pc, corrected p value.