Table 2

Visual and anatomical outcomes for 2 years

	Overall	2010–2012	2011–2013	2012–2014	2013–2015	2014–2016	2015–2017	P value for ANOVA	P value for trend test
Baseline BCVA (logMAR)	0.44±0.37	0.46±0.33	0.51±0.41	0.44±0.35	0.44±0.36	0.40±0.35	0.43±0.38	0.003	0.002
Good/poor (eyes)	735/1314	38/98	82/203	129/236	195/356	198/270	93/151	0.002	<0.001
Final BCVA (logMAR)	0.40±0.42	0.49±0.39	0.45±0.44	0.44±0.43	0.41±0.48	0.33±0.35	0.30±0.36	<0.001	<0.001
Good/poor (eyes)	949/1100	48/88	119/166	140/225	256/295	242/226	144/100	<0.001	<0.001
Difference of BCVA	−0.04±0.40	0.03±0.41	−0.06±0.38	0.00±0.43	−0.03±0.45	−0.07±0.34	−0.13±0.31	<0.001	<0.001
P value	<0.001	0.3527	0.0055	0.9523	0.1107	<0.001	<0.001	–	–
95% CI (logMAR)	−0.0622 to −0.0278	−0.0372 to 0.1035	−0.1078 to −0.0188	−0.0427 to 0.0454	−0.0680 to 0.0070	−0.0978 to −0.0361	−0.1658 to −0.0884	–	–
Baseline CMT (μm)	443.8±154.8	435.7±165.8	447.3±155.9	456.1±158.1	446.1±161.1	441.1±151.5	425.9±131.8	0.279	0.180
Final CMT (μm)	335.6±139.6	347.9±158.3	335.5±134.4	354.0±151.8	327.3±149.3	331.3±130.4	328.9±104.6	0.070	0.059
Difference of CMT (μm)	−108.2±186.8	−87.8±213.6	−111.8±192.1	−102.1±198.9	−118.8±186.2	−109.8±183.5	−97.1±150.7	0.456	0.766
P value	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	–	–
95% CI (logMAR)	−116.3 to −100.0	−124.9 to −50.7	−134.7 to −88.9	−122.7 to −81.5	−134.5 to −103.1	−126.5 to −93.1	−116.1 to −78.0	–	–

Data were presented as mean value ±SD.
ANOVA, analysis of variance; BCVA, best corrected visual acuity; CMT, central macular thickness.