Baseline risk factors associated with non-improvement of cornea staining at last follow-up visit (bivariate) n=407
| Variable | Central Baylor staining grade at last visit | Total | P value | |
| <2 Number (%) | ≥2 Number (%) | |||
| Total | 353 (86.7) | 54 (13.3) | 407 | |
| Schirmer’s test without local anesthesia | ||||
| ≤5 mm/5 min | 152 (83.5) | 30 (16.5) | 182 | 0.013* |
| >5 mm/5 min | 206 (91.6) | 19 (8.4) | 225 | |
| Tear break up time 2 | ||||
| <3 s | 201 (85.2) | 35 (14.8) | 236 | 0.042* |
| ≥3 s | 157 (91.8) | 14 (8.2) | 171 | |
| Autoimmune disease (RA, pSS, SLE, AS) | ||||
| Present | 52 (74.3) | 18 (25.7) | 70 | <0.001*** |
| Absent | 306 (90.8) | 31 (9.2) | 337 | |
| Rheumatoid arthritis | ||||
| Present | 28 (73.7) | 10 (26.3) | 38 | 0.005** |
| Absent | 330 (89.4) | 39 (10.6) | 369 | |
| Graft vs host disease | ||||
| Present | 9 (69.2) | 4 (30.8) | 13 | 0.035* |
| Absent | 349 (88.6) | 45 (11.4) | 394 | |
| Sjogren syndrome | ||||
| Present | 28 (77.8) | 8 (22.2) | 36 | 0.049* |
| Absent | 330 (88.9) | 41 (11.1) | 371 | |
| Systemic lupus erythematosus | ||||
| Present | 3 (75.0) | 1 (25.0) | 4 | 0.423 |
| Absent | 355 (88.1) | 48 (11.9) | 403 | |
| Ankylosing spondylitis | ||||
| Present | 2 (100.0) | 0 (0.0) | 2 | 0.600 |
| Absent | 356 (87.9) | 49 (12.1) | 405 | |
| Thyroid disease | ||||
| Present | 46 (92.0) | 4 (8.0) | 50 | 0.349 |
| Absent | 312 (87.4) | 45 (12.6) | 357 | |
| Gender | ||||
| Female | 285 (87.4) | 41 (12.6) | 326 | 0.504 |
| Male | 73 (90.1) | 8 (9.9) | 81 | |
Percentages in brackets are for variables across the row.
*P<0.05, **p<0.01, ***p<0.001.