Variable | Crude OR (95% CI) | P value | Adjusted OR (95% CI)† | P value | Adjusted OR (95% CI)‡ | P value | Adjusted OR (95% CI) § | P value | Adjusted OR (95% CI) ¶ | P value |
Rheumatoid arthritis | ||||||||||
Present | 3.0 (1.4 to 6.7) | 0.006** | 3.0 (1.3 to 6.8) | 0.007** | 3.1 (1.4 to 7.1) | 0.007** | 2.9 (1.3 to 6.9) | 0.013* | – | – |
Absent | 1 | 1 | 1 | 1 | ||||||
Sjogren syndrome | ||||||||||
Present | 2.3 (0.98 to 5.4) | 0.055 | 2.3 (0.95 to 5.3) | 0.064 | 2.3 (0.96 to 5.6) | 0.060 | 1.9 (0.8 to 4.7) | 0.173 | – | – |
Absent | 1 | 1 | 1 | 1 | ||||||
Systemic lupus erythematosus | ||||||||||
Present | 2.5 (0.3 to 24.2) | 0.439 | 2.3 (0.2 to 23.1) | 0.465 | 2.1 (0.2 to 20.8) | 0.542 | 1.7 (0.2 to 17.1) | 0.667 | – | – |
Absent | 1 | 1 | 1 | 1 | ||||||
Ankylosing spondylitis | ||||||||||
Present | 0.000 | 0.999 | 0.000 | 0.999 | 0.000 | 0.999 | 0.000 | 0.999 | – | – |
Absent | 1 | 1 | 1 | 1 | ||||||
Thyroid disease | ||||||||||
Present | 0.6 (0.2 to 1.8) | 0.353 | 0.6 (0.2 to 1.7) | 0.321 | 0.5 (0.2 to 1.6) | 0.246 | 0.5 (0.2 to 1.5) | 0.234 | – | – |
Absent | 1 | 1 | 1 | 1 | ||||||
Graft vs host disease | ||||||||||
Present | 3.4 (1.0 to 11.7) | 0.046* | 3.6 (1.0 to 12.6) | 0.042* | 3.9 (1.1 to 13.9) | 0.034* | 3.2 (0.9 to 11.7) | 0.083 | – | – |
Absent | 1 | 1 | 1 | 1 | ||||||
Autoimmune disease (RA, Sjogren, SLE, AS) | ||||||||||
Present | 3.4 (1.8 to 6.6) | <0.001*** | 3.4 (1.8 to 6.7) | <0.001*** | 3.6 (1.8 to 7.0) | <0.001*** | 3.1 (1.5 to 6.3) | 0.002** | – | – |
Absent | 1 | 1 | 1 | 1 | ||||||
Schirmer’s test without local anesthesia | ||||||||||
≤5 mm/5 min | 2.1 (1.2 to 3.9) | 0.015* | 2.2 (1.2 to 4.1) | 0.013* | 2.2 (1.2 to 4.0) | 0.017* | – | – | 1.7 (0.9 to 3.3) | 0.110 |
>5 mm/5 min | 1 | 1 | 1 | 1 | ||||||
Tear break up time | ||||||||||
<3 s | 2.0 (1.0 to 3.8) | 0.045* | 1.9 (1.0 to 3.8) | 0.048* | 1.8 (0.9 to 3.6) | 0.073 | – | – | 1.9 (0.9 to 3.7) | 0.074 |
≥3 s | 1 |
Dependet Variables: 1 = staining grade at last visit <2; 2 = staining grade at last visit ≥ 2.
*P<0.05, **p<0.01, ***p<0.001.
†Adjusted by age, gender.
‡Adjusted by age, gender, allergies, previous ocular surgery, contact lens use, MG expressibility, MG regularity, MG plugs.
§Adjusted by age, gender, allergies, previous ocular surgery, contact lens use, MG expressibility, MG regularity, MG plugs, Schirmer’s disease, tear break up time.
¶Adjusted by age, gender, allergies, previous ocular surgery, contact lens use, MG expressibility, MG regularity, MG plugs, autoimmune disease (RA, pSS, SLE, AS).
AS, ankylosing spondylitis; pSS, primary Sjogren syndrome; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus.