Table 1

Baseline demographic characteristics and Angio 3×3 mm vessel density metrics considering distinct DRSS stages of the disease

DemographicsHealthyETDRS 10ETDRS 20ETDRS 35ETDRS 43ETDRS 47–53
N381618391715
Age (years)65.8±10.268.8±4.864.8±7.066.9±9.566.6±7.965.4±7.5
Sex (Male/female)20/189/710/828/1113/410/5
Diabetes duration (years)18.5±11.320.8±13.821.6±10.721.7±5.916.2±8.8
HbA1c (%)6.2±1.07.1±1.17.4±1.377.6±0.87.5±1.38.1±1.1
BCVA (letters)83.0±4.383.4±4.484.3±6.384.2±4.582.4±6.880.1±8.0
Vessel density
SCPm mm-1
(Inner ring (5. 10)°)14.7±1.312.6±2.5
p=0.009
13.2±1.7
p=0.005
12.1±2.0
p=0.000
12.2±1.9
p=0.010
12.0±1.3
p=0.001
Vessel density
DCP, mm-1
(Inner ring (5. 10)°)14.5±1.511.9±2.8
p=0.003
13.0±1.6
p=0.012
12.9±2.3
p=0.014
12.3±2.5
p=0.045
11.6±1.2
p=0.001
Vessel density
FR, mm-1
(Inner ring (5. 10)°)17.9±1.115.7±2.8
p=0.009
16.6±1.3
p=0.008
16.0±2.0
p=0.000
15.4±2.0
p=0.010
15.2±1.4
p=0.000
Thickness
retina, µm
(Central SF (0. 5)°)271.4±20.6276.3±29.6
p=0.675
277.4±38.3
p=0.952
282.2±29.0
p=0.201
274.8±23.4
p=0.677
305.0±49.6
p=0–132
(Inner ring (5. 10)°)332.8±17.7330.1±12.7
p=0.646
331.7±14.5
p=0.971
328.1±17.2
p=0.509
333.4±17.8
p=0.850
346.3±30.3
p=0.338
  • Vessel density values, obtained using PlexElite 3 mm×3 mm, and retinal thickeness values were calculated using Zeiss MultiLayer segmentation algorithm. Comparisons between diabetic individuals and healthy controls were performed using Mann-Whitney U-test. Bonferroni correction was applied to vessel density comparisons setting the statistical significance to p<0.0167, otherwise p<0.05.

  • Data are presented as mean±SD.

  • Statistical significance highlighted in bold.

  • BCVA, best corrected visual acuity; DCP, deep capillary plexus; FR, full retina; HbA1c, glycated haemoglobin; SCP, superficial capillary plexus.