Table 2

Functional readouts of the treated patients’ eyes

IDP1P1P2P3P4P4P8Average
EyeRELELELERELELE
BCVA
Baseline0.1250.160.0250.06FCFC0.2
Month 10.1250.160.0250.10.0250.030.2
Month 30.20.10.0250.1250.020.020.25
FST blue (dB)Baseline−0.83−9.710.22−0.72−4.15−0.91−7.60−3.39
Month 1−26.20−18.84−11.11−44.00−2.06−5.55−34.73−20.36
Month 3−18.77−25.69−6.29−29.10−6.07−6.83−23.44−16.60
FST red (dB)Baseline1.5−1.933.70.853.182.73−4.210.83
Month 1−7.72−9.1−0.48−18.684.85−6.09−10.88−6.87
Month 3−11.05−7.021.96−9.56−0.231.58−6.49−4.40
DAC blue average (dB)Baseline−1.100.000.00−1.400.00−2.70−15.20−2.91
Month 1−18.50−14.80−0.60−25.400.00−0.50−21.60−11.63
Month 3−21.90−18.700.00−28.400.000.00−24.00−13.29
DAC red average (dB)Baseline0.00−0.750.00−3.200.000.00−3.10−1.01
Month 1−4.20−2.200.00−14.100.000.00−6.30−3.83
Month 3−5.20−3.200.00−12.900.000.00−5.80−3.87
CPC rods average (relMCA)Baseline0.000.210.060.000.410.590.890.31
Month 11.071.180.062.580.480.714.611.53
Month 32.000.320.003.520.350.414.071.52
CPC cones average
(relMCA)
Baseline5.401.270.374.604.304.888.034.12
Month 16.374.623.9214.754.913.348.376.61
Month 34.205.120.9014.004.415.035.545.60
  • The functional readouts of the treated eyes are shown for the baseline, 1 month and 3 months after the injection. BCVA is shown in decimal values. FST is shown in dB (0 dB=0.01 cd/m2). DAC values show the average sensitivity in the 15 degrees macular area, representing the treated region (0 dB=17.6 cd/m2). CPC values show the average relative maximal constriction amplitude (relMCA) in 15 degrees macular area, representing the treated region.

  • BCVA, best corrected visual acuity; CPC, chromatic pupil campimetry; DAC, dark-adapted chromatic perimeter; FC, finger counting; FST, full-field stimulus threshold; LE, left eye; RE, right eye.