Table 2

Mean difference in intraocular pressure at 3 months (95% credible interval) derived from the NMA

Placebo−5.39−5.59−4.72−5.42−5.00−1.97−2.86−2.53−3.66−2.53−3.24−2.55−4.79−3.73−4.84
(−6.60 to −4.21)(−6.43 to−4.75)(−5.39 to−4.04)(−6.68 to−4.16)(−6.15 to−3.88)(−2.88 to−1.06)(−4.65 to−1.12)(−3.32 to−1.75)(−4.48 to−2.85)(−3.52 to−1.56)(−4.40 to−2.09)(−3.33 to−1.78)(−5.64 to−3.95)(−4.36 to−3.10)(−5.69 to−3.98)
5.39Bimatoprost 0.01%−0.200.67−0.020.393.422.532.861.732.852.152.840.601.660.55
(4.21 to 6.60)(−1.41 to1.03)(−0.44 to1.80)(−1.59 to1.55)(−1.06 to1.82)(2.11 to 4.75)(0.51 to 4.51)(1.59 to 4.15)(0.47 to 2.99)(1.45 to 4.27)(0.65 to 3.65)(1.55 to 4.13)(−0.70 to1.92)(0.52 to 2.81)(−0.60 to1.72)
5.590.20Bimatoprost 0.03%0.880.170.593.622.733.061.933.062.353.040.801.860.75
(4.75 to 6.43)(−1.03 to1.41)(0.26 to 1.48)(−1.07 to1.42)(−0.54 to1.69)(2.69 to 4.55)(0.94 to 4.47)(2.18 to 3.95)(1.09 to 2.76)(2.01 to 4.10)(1.18 to 3.50)(2.12 to 3.94)(−0.12 to1.71)(1.24 to 2.48)(0.08 to 1.43)
4.72−0.67−0.88Latanoprost−0.70−0.292.751.852.181.052.181.472.17−0.080.99−0.12
(4.04 to 5.39)(−1.80 to0.44)(−1.48 to−0.26)(−1.83 to0.43)(−1.28 to0.69)(2.01 to 3.49)(0.13 to 3.53)(1.46 to 2.92)(0.41 to 1.69)(1.27 to 3.09)(0.41 to 2.53)(1.41 to 2.92)(−0.85 to0.70)(0.58 to 1.39)(−0.75 to0.52)
5.420.02−0.170.70Latanoprostene Bunod0.413.452.552.891.752.882.172.870.621.690.58
(4.16 to 6.68)(−1.55 to1.59)(−1.42 to1.07)(−0.43 to1.83)(−1.07 to1.87)(2.12 to 4.77)(0.55 to 4.52)(1.60 to 4.17)(0.49 to 3.02)(1.47 to 4.29)(0.69 to 3.65)(1.55 to 4.17)(−0.68 to1.92)(0.58 to 2.80)(−0.69 to1.85)
5.00−0.39−0.590.29−0.41Tafluprost3.042.142.471.342.471.762.460.211.280.17
(3.88 to 6.15)(−1.82 to1.06)(−1.69 to0.54)(−0.69 to1.28)(−1.87 to1.07)(1.83 to 4.25)(0.20 to 4.05)(1.31 to 3.66)(0.21 to 2.49)(1.18 to 3.77)(0.38 to 3.15)(1.27 to 3.65)(−0.97 to1.41)(0.30 to 2.27)(−0.92 to1.28)
1.97−3.42−3.62−2.75−3.45−3.04Unoprostone−0.90−0.56−1.70−0.57−1.28−0.58−2.82−1.76−2.87
(1.06 to 2.88)(−4.75 to−2.11)(−4.55 to−2.69)(−3.49 to−2.01)(−4.77 to−2.12)(−4.25 to−1.83)(−2.73 to0.90)(−1.50 to0.38)(−2.63 to−0.75)(−1.69 to0.56)(−2.52 to−0.03)(−1.57 to0.41)(−3.83 to−1.81)(−2.53 to−0.99)(−3.82 to−1.92)
2.86−2.53−2.73−1.85−2.55−2.140.90Apraclonidine0.33−0.800.33−0.380.31−1.93−0.86−1.98
(1.12 to 4.65)(−4.51 to−0.51)(−4.47 to−0.94)(−3.53 to−0.13)(−4.52 to−0.55)(−4.05 to−0.20)(−0.90 to2.73)(−1.43 to2.14)(−2.54 to0.99)(−1.51 to2.21)(−2.28 to1.54)(−1.46 to2.13)(−3.70 to−0.13)(−2.49 to0.81)(−3.73 to−0.18)
2.53−2.86−3.06−2.18−2.89−2.470.56−0.33Betaxolol−1.130.00−0.71−0.02−2.26−1.20−2.31
(1.75 to 3.32)(−4.15 to−1.59)(−3.95 to−2.18)(−2.92 to−1.46)(−4.17 to−1.60)(−3.66 to−1.31)(−0.38 to1.50)(−2.14 to1.43)(−1.99 to−0.29)(−1.06 to1.03)(−1.90 to0.46)(−0.87 to0.81)(−3.17 to−1.37)(−1.88 to−0.52)(−3.21 to−1.40)
3.66−1.73−1.93−1.05−1.75−1.341.700.801.13Brimonidine1.130.421.11−1.13−0.06−1.17
(2.85 to 4.48)(−2.99 to−0.47)(−2.76 to−1.09)(−1.69 to−0.41)(−3.02 to−0.49)(−2.49 to−0.21)(0.75 to 2.63)(−0.99 to2.54)(0.29 to 1.99)(0.21 to 2.04)(−0.75 to1.59)(0.23 to 1.99)(−2.05 to−0.21)(−0.70 to0.57)(−2.02 to−0.32)
2.53−2.85−3.06−2.18−2.88−2.470.57−0.330.00−1.13Brinzolamide−0.71−0.01−2.26−1.19−2.30
(1.56 to 3.52)(−4.27 to−1.45)(−4.10 to−2.01)(−3.09 to−1.27)(−4.29 to−1.47)(−3.77 to−1.18)(−0.56 to1.69)(−2.21 to1.51)(−1.03 to1.06)(−2.04 to−0.21)(−2.01 to0.60)(−0.99 to0.95)(−3.34 to−1.17)(−2.06 to−0.32)(−3.36 to−1.24)
3.24−2.15−2.35−1.47−2.17−1.761.280.380.71−0.420.71Carteolol0.69−1.55−0.48−1.59
(2.09 to 4.40)(−3.65 to−0.65)(−3.50 to−1.18)(−2.53 to−0.41)(−3.65 to−0.69)(−3.15 to−0.38)(0.03 to 2.52)(−1.54 to2.28)(−0.46 to1.90)(−1.59 to0.75)(−0.60 to2.01)(−0.51 to1.89)(−2.68 to−0.42)(−1.46 to0.50)(−2.76 to−0.42)
2.55−2.84−3.04−2.17−2.87−2.460.58−0.310.02−1.110.01−0.69Dorzolamide−2.24−1.18−2.29
(1.78 to 3.33)(−4.13 to−1.55)(−3.94 to−2.12)(−2.92 to−1.41)(−4.17 to−1.55)(−3.65 to−1.27)(−0.41 to1.57)(−2.13 to1.46)(−0.81 to0.87)(−1.99 to−0.23)(−0.95 to0.99)(−1.89 to0.51)(−3.18 to−1.29)(−1.88 to−0.47)(−3.21 to−1.35)
4.79−0.60−0.800.08−0.62−0.212.821.932.261.132.261.552.24Levobunolol1.06−0.05
(3.95 to 5.64)(−1.92 to0.70)(−1.71 to0.12)(−0.70 to0.85)(−1.92 to0.68)(−1.41 to0.97)(1.81 to 3.83)(0.13 to 3.70)(1.37 to 3.17)(0.21 to 2.05)(1.17 to 3.34)(0.42 to 2.68)(1.29 to 3.18)(0.38 to 1.75)(−0.98 to0.89)
3.73−1.66−1.86−0.99−1.69−1.281.760.861.200.061.190.481.18−1.06Timolol−1.11
(3.10 to 4.36)(−2.81 to−0.52)(−2.48 to−1.24)(−1.39 to−0.58)(−2.80 to−0.58)(−2.27 to−0.30)(0.99 to 2.53)(−0.81 to2.49)(0.52 to 1.88)(−0.57 to0.70)(0.32 to 2.06)(−0.50 to1.46)(0.47 to 1.88)(−1.75 to−0.38)(−1.76 to−0.46)
4.84−0.55−0.750.12−0.58−0.172.871.982.311.172.301.592.290.051.11Travoprost
(3.98 to 5.69)(−1.72 to0.60)(−1.43 to−0.08)(−0.52 to0.75)(−1.85 to0.69)(−1.28 to0.92)(1.92 to 3.82)(0.18 to 3.73)(1.40 to 3.21)(0.32 to 2.02)(1.24 to 3.36)(0.42 to 2.76)(1.35 to 3.21)(−0.89 to0.98)(0.46 to1.76)

  • Embedded Image, PGA

  • Embedded Image, others

  • Results presented in bold are significant.

  • Mean difference under 0 favours the drug in the column.

  • NAM, network meta-analysis; PGA, prostaglandin analogue.