Summary of antibiotic susceptibility of infectious keratitis in Nottingham, UK, between 2007–2013 and 2014–2019
| Organisms | 2007–2019 | 2007–2013 | 2014–2019 | P value* |
| n (%) | n (%) | n (%) | ||
| Gram-positive | ||||
| Penicillin† | 260/283 (91.9) | 136/141 (96.5) | 124/142 (87.3) | 0.005 |
| Cefuroxime | 25/25 (100.0) | 17/17 (100.0) | 8/8 (100.0) | 1.0 |
| Gentamicin | 177/186 (95.2) | 97/101 (96.0) | 80/85 (94.1) | 0.73 |
| Ciprofloxacin | 164/182 (90.1) | 92/100 (92.0) | 72/82 (87.8) | 0.35 |
| Levofloxacin | 41/41 (100.0) | 16/16 (100.0) | 25/25 (100.0) | 1.0 |
| Gram-negative | ||||
| Penicillin† | 36/80 (45.0) | 18/38 (47.4) | 18/52 (34.6) | 0.22 |
| Cefuroxime | 65/80 (81.3) | 30/38 (78.9) | 35/42 (83.3) | 0.62 |
| Amikacin | 172/174 (98.9) | 91/92 (98.9) | 81/82 (98.8) | 1.0 |
| Gentamicin | 174/177 (98.3) | 93/94 (98.9) | 81/83 (97.6) | 0.6 |
| Ciprofloxacin | 175/179 (97.8) | 92/94 (97.9) | 83/85 (97.6) | 1.0 |
| Levofloxacin | 53/53 (100.0) | 16/16 (100.0) | 37/37 (100.0) | 1.0 |
*Chi-square or Fisher’s exact test (if any variable was <5) was performed to determine the significant difference between the two time periods. Significant p value is underlined.
†Penicillin group includes penicillin, amoxicillin and flucloxacillin.