Table 3

Linear regression model showing the relationship of lamina cribrosa depth from the anterior sclera reference plane with its determinants

VariablesChinese (n=628)Indian (n=768)
UnivariableMultivariableUnivariableMultivariable
Estimate95% CIP valueEstimate95% CIP valueEstimate95% CIP valueEstimate95% CIP value
Age, year0.82(−0.19 to 1.83)0.111.88(0.39 to 3.37) 0.014 −0.4(−1.47 to 0.67)0.464−0.09(−1.18 to 0.99)0.866
Gender (ref: male)−19.48(−34.26 to 4.69) 0.01 −11.88(−31.18 to 7.42)0.229−41.06(−56.6 to 25.48) <0.001 −44.32(−60.2 to 28.44) <0.001
BCVA, unit16.24(−50.78 to 83.26)0.6352.61(−67.51 to 72.74)0.942
IOP, mm Hg1.2(−1.89 to 4.29)0.4471.08(−2.13 to 4.3)0.509
OPP, mm Hg0.28(−0.7 to 1.26)0.575−0.37(−1.48 to 0.75)0.518
CCT, µm−0.11(−0.34 to 0.12)0.332−0.01(−0.26 to 0.23)0.921
Axl, mm−5.82(−11.86 to 0.21)0.059−0.24(−8.83 to 8.35)0.957−12.45(−20.74 to 4.16) 0.003 −13.31(−21.7 to 4.91) 0.002
RNFL, µm0.63(−0.31 to 1.58)0.1910.64(−0.35 to 1.62)0.2070.64(−0.12 to 1.4)0.1010.84(0.11 to 1.56) 0.025
ChT, µm0.33(0.19 to 0.46) <0.001 0.34(0.15 to 0.53) <0.001 0.65(0.48 to 0.82) <0.001 0.49(0.32 to 0.67) <0.001
VCDR (per 0.1)5.41(−3.23 to 14.05)0.2210.63(−0.67 to 21.93)0.06627.34(19.38 to 35.3) <0.001 30.04(22.02 to 38.05) <0.001
Disc size, mm−59.21(−98.01 to 20.41) 0.003 −17.86(−77.32 to 41.6)0.556−49.51(−93.2 to 5.83) 0.027 −82.12(−128.69 to 35.55) <0.001
  • Axl, axial length; BCVA, best-corrected visual acuity; CCT, central corneal thickness; Cht, choroidal thickness; IOP, intraocular pressure; OPP, ocular perfusion pressure; RNFL, retinal nerve fibre layer; VCDR, vertical cup disc ratio.