Table 2

Comparison of optical coherence tomography angiography measures after adjusting for age, gender and inter-eye correlation

OCTA parametersNMOSD vs POAGNMO+ON vs G-A
NMOSD value (SD)POAG value (SD)NMO+ON value (SD)G-A value (SD)
Average pRNFL 82.28 (19.89)74.54 (16.58)68.99 (14.27)62.40 (11.23)
S pRNFL100.14 (28.82)93.41 (28.88)83.40 (24.21)74.26 (23.60)
T pRNFL60.64 (20.26)61.28 (15.33)49.23 (13.43)51.90 (10.67)
I pRNFL106.31 (32.87)***78.71 (22.11)85.93 (26.20)***63.42 (11.33)
N pRNFL62.28 (11.90)* 64.93 (11.24)57.78 (10.30)60.00 (9.36)
Average GC-IPL 70.26 (14.07)68.26 (11.12)60.79 (10.54)61.18 (8.39)
S GC-IPL70.80 (14.40)71.52 (13.20)61.49 (11.43)* 64.02 (11.33)
TS GC-IPL70.26 (13.27)68.34 (13.06)62.11 (11.37)60.28 (10.44)
TI GC-IPL71.35 (13.26)***60.94 (9.72)63.10 (10.96)***54.78 (5.37)
I GC-IPL69.47 (13.48)* 63.82 (9.87)60.64 (10.13)57.84 (6.89)
NI GC-IPL69.41 (16.05)70.90 (12.80)58.35 (11.03)**63.6 (11.05)
NS GC-IPL70.92 (16.21)**74.64 (14.00)59.95 (11.89)**67.56 (13.50)
Whole VD 14.47 (3.45)***16.83 (1.51)13.66 (3.46)***16.19 (1.57)
Central VD 5.79 (3.33)***8.48 (2.91)5.08 (2.84)***8.51 (3.10)
Whole PD 0.3504 (0.0870)***0.4149 (0.0384)0.3295 (0.0887)***0.3996 (0.0397)
Central PD 0.1262 (0.0768)***0.1885 (0.0666)0.1094 (0.0647)***0.1893 (0.0704)
FAZ area 0.2473 (0.1210)***0.2956 (0.1282)0.2496 (0.1257)***0.2718 (0.1090)
  • OCTA values are presented as mean (SD). VD, PD and FAZ were measured in the superficial capillary plexus. pRNFL and GC-IPL thicknesses are expressed in μm, VD and PD in mm-1, FAZ area in mm2.

  • *p<0.05; **p<0.01; ***p<0.001.

  • GC-IPL, ganglion cell-inner plexiform layer; FAZ, foveal avascular zone; G-A, advanced glaucoma; I, inferior; N, nasal; NI, nasal-inferior; NMOSD, neuromyelitis optica spectrum disorder; NS, nasal-superior; OCTA, optical coherence tomography angiography; ON, optic neuritis; PD, perfusion density; POAG, primary open-angle glaucoma; pRNFL, peripapillary retinal nerve fibre layer; S, superior; T, temporal; TI, temporal-inferior; TS, temporal-superior; VD, vessel density.