Mixed model estimates of risk factors for longitudinal crude changes of corneal endothelial cells parameters over 72 months
| Multivariate models | Estimate (95% CI) | P value |
| Endothelial cell density (per mm2) | ||
| Age at baseline (years) | −1.45 (−2.32 to −0.58) | 0.001 |
| Gender (male as reference) | −5.27 (−16.77 to 6.24) | 0.37 |
| Group (non-LPI eye as reference) | 6.07 (−2.46 to 14.61) | 0.16 |
| Time (month) | −1.60 (−1.72 to −1.48) | <0.001 |
| Time×group | −0.32 (−0.49 to −0.15) | 0.0002 |
| Mean cell area (μm2) | ||
| Age at baseline (years) | 0.18 (0.05 to 0.31) | 0.007 |
| Gender (male as reference) | 1.21 (−0.51 to 2.93) | 0.17 |
| Group (non-LPI eye as reference) | −0.68 (−2.01 to 0.65) | 0.32 |
| Time (month) | 0.23 (0.22 to 0.25) | <0.001 |
| Time×group | 0.03 (0.01 to 0.06) | 0.008 |
| Hexagonality (%) | ||
| Age at baseline (years) | 0 (−0.07 to 0.07) | 0.98 |
| Gender (male as reference) | 0.62 (−0.30 to 1.54) | 0.18 |
| Group (non-LPI eye as reference) | −0.07 (−0.77 to 0.63) | 0.85 |
| Time (month) | 0 (0 to 0.01) | 0.28 |
| Time×group | 0.01 (−0.01 to 0.02) | 0.28 |
Time×group=interaction between time and group. Bold indicates statistical significance.
LPI, laser peripheral iridotomy.