Changes of corneal endothelial cell parameters for YAG laser peripheral iridotomy treated and fellow eyes at each follow-up
| Month | Absolute change (mean (95% CI)) | Percentage change (% (95% CI)) | P value | ||||
| LPI eye | Non-LPI eye | Treatment effect | LPI eye | Non-LPI eye | Treatment effect | ||
| Endothelial cell density (per mm2) | |||||||
| 6 | −11.8 (−20.2 to −3.3) | −20.3 (−28.8 to −11.9) | 8.6 (−2.9 to 20.1) | −0.39 (−0.72 to −0.06) | −0.65 (−0.98 to −0.32) | 0.26 (−0.19 to 0.71) | 0.14 |
| 18 | −25.4 (−33.8 to −17) | −26.4 (−34.8 to −17.9) | 1.0 (−10.5 to 12.4) | −0.97 (−1.3 to −0.63) | −0.93 (−1.26 to −0.6) | −0.03 (−0.48 to 0.41) | 0.87 |
| 36 | −65.5 (−74.2 to −56.9) | −62.4 (−71.1 to −53.7) | −3.1 (−14.9 to 8.7) | −2.5 (−2.84 to −2.16) | −2.38 (−2.72 to −2.04) | −0.12 (−0.58 to 0.34) | 0.61 |
| 54 | −117.9 (−126.9 to −108.9) | −106.3 (−115.3 to −97.2) | −11.6 (−23.9 to 0.7) | −4.56 (−4.92 to −4.21) | −4.08 (−4.44 to −3.73) | −0.48 (−0.96 to 0) | 0.06 |
| 72 | −127.8 (−137 to −118.6) | −108.4 (−117.8 to −99) | −19.4 (−32.1 to −6.7) | −4.93 (−5.3 to −4.57) | −4.2 (−4.57 to −3.83) | −0.74 (−1.23 to −0.24) | 0.003 |
| Mean cell area (μm2) | |||||||
| 6 | 1.1 (−0.2 to 2.3) | 1.8 (0.6 to 3.1) | −0.8 (−2.5 to 0.9) | 0.35 (0.05 to 0.66) | 0.6 (0.29 to 0.9) | −0.24 (−0.67 to 0.18) | 0.38 |
| 18 | 3.5 (2.2 to 4.7) | 3.7 (2.4 to 4.9) | −0.2 (−1.9 to 1.5) | 0.94 (0.63 to 1.25) | 1.04 (0.73 to 1.35) | −0.1 (−0.53 to 0.33) | 0.81 |
| 36 | 9.0 (7.7 to 10.3) | 9.3 (8 to 10.5) | −0.3 (−2 to 1.5) | 2.4 (2.08 to 2.72) | 2.43 (2.12 to 2.75) | −0.03 (−0.47 to 0.4) | 0.75 |
| 54 | 17.3 (16 to 18.6) | 15.2 (13.9 to 16.6) | 2.1 (0.2 to 3.9) | 4.48 (4.15 to 4.8) | 3.99 (3.66 to 4.33) | 0.48 (0.02 to 0.94) | 0.03 |
| 72 | 16.5 (15.2 to 17.9) | 15.1 (13.7 to 16.4) | 1.5 (−0.4 to 3.4) | 4.32 (3.98 to 4.66) | 3.91 (3.57 to 4.26) | 0.4 (−0.07 to 0.88) | 0.13 |
| Hexagonality (%) | |||||||
| 6 | 0.16 (−0.48 to 0.80) | 0.15 (−0.49 to 0.80) | 0 (−0.88 to 0.89) | 2.19 (0.93 to 3.45) | 2.31 (1.05 to 3.58) | −0.13 (−1.85 to 1.59) | 0.99 |
| 18 | 0.06 (−0.58 to 0.70) | 0.28 (−0.37 to 0.93) | −0.22 (−1.11 to 0.67) | 2.15 (0.89 to 3.42) | 2.66 (1.39 to 3.93) | −0.5 (−2.23 to 1.23) | 0.63 |
| 36 | 0.12 (−0.54 to 0.77) | 0.07 (−0.59 to 0.73) | 0.05 (−0.86 to 0.96) | 2.24 (0.95 to 3.53) | 2.2 (0.9 to 3.49) | 0.04 (−1.72 to 1.81) | 0.92 |
| 54 | 1.20 (0.52 to 1.88) | 0.37 (−0.31 to 1.06) | 0.83 (−0.11 to 1.78) | 4.16 (2.83 to 5.49) | 2.83 (1.49 to 4.18) | 1.33 (−0.51 to 3.16) | 0.08 |
| 72 | 0.53 (−0.16 to 1.22) | 0.40 (−0.31 to 1.11) | 0.13 (−0.84 to 1.10) | 2.89 (1.53 to 4.25) | 3.08 (1.69 to 4.47) | −0.19 (−2.07 to 1.7) | 0.80 |
Treatment effect defined as the change in the LPI group minus the change in the control group. P value for the differences between groups. Bold indicates statistical significance.
LPI, laser peripheral iridotomy.