Summary of microbiological profiles of infectious keratitis in Nottingham, UK, between 2007–2013 and 2014–2019
| Organisms | 2007–2019 | 2007–2013 | 2014–2019 | P value* |
| n=572; n (%) | n=282; n (%) | n=290; n (%) | ||
| Gram-positive | 308 (53.8) | 153 (54.3) | 155 (53.4) | 0.53 |
| S. aureus | 91 (15.9) | 49 (17.4) | 42 (14.5) | 0.34 |
| CoNS | 75 (13.1) | 39 (13.8) | 36 (12.4) | 0.64 |
| Streptococci spp | 77 (13.5) | 37 (13.1) | 40 (13.8) | 0.74 |
| Bacilli | 63 (11.0) | 28 (9.9) | 35 (12.1) | 0.35 |
| Others† | 2 (0.3) | 0 (0.0) | 2 (0.7) | 0.5 |
| Gram-negative | 223 (39.0) | 108 (38.3) | 115 (39.7) | 0.74 |
| P. aeruginosa | 135 (23.6) | 67 (23.8) | 68 (23.4) | 0.66 |
| Moraxella spp | 37 (6.5) | 8 (2.8) | 29 (10.0) | <0.001 |
| Klebsiella spp | 11 (1.9) | 10 (3.5) | 1 (0.3) | 0.004 |
| Others‡ | 40 (7.0) | 23 (8.2) | 17 (5.9) | 0.21 |
| Fungi | 17 (3.0) | 10 (3.5) | 7 (2.4) | 0.43 |
| Yeast | 10 (1.7) | 6 (2.1) | 4 (1.4) | 0.91 |
| Filamentous | 7 (1.2) | 4 (1.4) | 3 (1.0) | 0.91 |
| Acanthamoeba | 24 (4.2) | 11 (3.9) | 13 (4.5) | 0.72 |
*Chi-square or Fisher’s exact test (if any variable was <5) was used to detect any significant changing trend of the microbiological profiles between 2017–2013 and 2014–2019. The analysis was performed at two levels; the first level evaluated the changes among Gram-positive and Gram-negative organisms, fungi and acanthamoeba; and the second level examined the changes of the subtypes of the organisms within the four groups. Significant p values (<0.05) are underlined.
†Others include Enterococci spp.
‡Others Include Achromobacter spp, Acinetobacter spp, Citrobacter koseri, Enterobacter spp, Kingella spp, Serratia marcescens, Haaemophilus spp, Proteus spp, Neisseria spp and Stenotrophomonas maltophilia.
CoNS, coagulase-negative staphylococcus.