Table 3

Univariable analysis of recipient, donor and surgery parameters for developing early graft failure after DMEK surgery

All consecutive performed DMEK (n=752)
Early graft failure (n=85) (%)OR95% CIP value
Recipient parameters
Age, years1.03 (per 1 unit)1.00 to 1.060.037
Sex1.550.98 to 2.440.06
 Male14
 Female9
Baseline IOP, mm Hg1.03 (per 1 unit)0.96 to 1.100.43
Baseline CCT, µm1.00 (per 1 unit)1.00 to 1.010.43
Indication, FED0.80.39 to 1.620.53
 Yes11
 No14
Indication, PBK1.590.45 to 5.610.47
 Yes16
 No11
Indication, graft failure1.240.47 to 3.270.66
 Yes14
 No11
Lens status, PPC1.590.87 to 2.890.13
 Yes12
 No8
Ocular comorbidities, except cataract0.810.41 to 1.630.56
 Yes10
 No12
Donor parameters
Age, years0.98 (per 1 unit)0.95 to 1.010.15
Sex1.120.70 to 1.800.64
 Male12
 Female11
Graft diameter, mm
 <8.520
 8.580.370.21 to 0.64<0.001
 >8.5241.250.58 to 2.740.57
ECD, cells/mm21.00 (per 1 unit)1.00 to 1.000.65
Complicated graft preparation2.150.70 to 6.620.17
 Yes21
 No11
Surgery parameters
Surgical complication2.831.50 to 5.320.001
 Yes24
 No10
Diameter descemetorhexis, mm
 <8.511
 8.580.670.33 to 1.330.25
 >8.5151.410.76 to 2.610.27
Recipient donor sex mismatch1.020.65 to 1.610.93
 Yes11
 No11
Surgery date after 20150.320.19 to 0.54<0.001
 Yes9
 No24
Triple procedure0.840.33 to 2.190.73
 Yes10
 No11
Phakic DMEK0.330.08 to 1.400.08
 Yes4
 No12
PPC vs phakic DMEK3.150.75 to 13.350.1
PPC vs triple1.290.49 to 3.340.61
PPC and triple vs phakic DMEK3.090.73 to 12.980.11
Eye undergoing surgery0.780.49 to 1.230.28
 Left10
 Right13
  • CCT, central cornea thickness; DMEK, Descemet membrane endothelial keratoplasty; ECD, endothelial cell density; FED, Fuchs endothelial dystrophy; IOP, intraocular pressure; PBK, pseudophakic bullous keratopathy; PPC, pseudophakic, posterior chamber.