Table 1

Summary of reported cases of corneal graft rejection following vaccination

StudyPatient, age, lateralityEye/episodeVaccineInterval postgraftType of graftInterval postvaccinationOutcome
Solomon and Frucht-Pery8Patient 1,
80, bilateral,
simultaneous
OD/firstInfluenza (trivalent vaccine for the inactivated strains of A-Beijing-32/92-H3N2, A-Texas-36/91-H1N1 and B-Panama-45/90 of the influenza virus)11 yearsPK6 weeksResolved with topical and sub-Tenon’s steroids and systemic steroids (80 mg prednisolone orally per day).
OS/firstInfluenza (trivalent vaccine for the inactivated strains of A-Beijing-32/92-H3N2, A-Texas-36/91-H1N1 and B-Panama-45/90 of the influenza virus)8 yearsPK6 weeks and 3 daysResolved with topical and sub-Tenon’s steroids and systemic steroids (80 mg prednisolone orally per day).
Wertheim et al7Patient 2,
67, unilateral
OS/firstInfluenza (Sanofi-Pasteur MSD, UK)8 monthsPK2 weeksResolved with topical steroids.
Patient 3,
67, unilateral, consecutive
OD/firstInfluenza (Sanofi-Pasteur MSD, UK)7 monthsPK3 weeksResolved with topical steroids.
OD/second
(1 year after, following annual vaccination)
Influenza1 year and 7 monthsPK4 weeksResolved with topical steroids.
Hamilton et al10Patient 4,
33, unilateral
OD/firstInfluenza
(Fluvax, CSL, Parkville, Victoria, Australia)
2 years and 7 monthsDALK3 weeksResolved with topical steroids but residual central stromal haze with visual loss from prior to rejection.
Vignapiano et al9Patient 5,
48, unilateral
N/AYellow feverN/AN/A3 weeksResolved with topical and systemic steroids.
  • DALK, deep anterior lamellar keratoplasty; N/A, not available; OD, right eye; OS, left eye; PK, penetrating keratoplasty.