Posterior segment structure | Experimental condition (cell line/animal used) | Dominant receptor expression | Other receptors expressed | Detection method | References |
Retina | Adult Sprague Dawley rat eye tissue | S1P1 |
| qRT-PCR | 33 |
Postnatal mouse eye tissue | S1P1 |
| qRT-PCR | 33 | |
Photoreceptors | 661W photoreceptor cell line | S1P2 |
| qPCR | 35 |
RPE | ARPE-19 cell line | S1P2 |
| qPCR | 57 |
ARPE-19 cell line | S1P3 |
| Semiquantitative RT-PCR | 43 | |
Primary human RPE | S1P1, S1P2, S1P3 |
| RT-PCR | 42 | |
RPE-choroid | Adult Sprague Dawley rats | S1P3 | – | qRT-PCR | 33 |
Retinal vasculature endothelial cells | Primary human retinal endothelial cells isolated from donor tissue | S1P2 |
| qRT-PCR | 44 |
Optic nerve | Postnatal mouse eye tissue | S1P3 |
| qRT-PCR | 33 |
qPCR, quantitative real-time PCR; qRT-PCR, quantitative reverse transcriptase PCR; RPE, retinal pigmented epithelium; RT-PCR, reverse transcriptase PCR; S1P, sphingosine 1-phosphate.