Table 3

The univariate and multiple regression analysis of whole image vessel density at NFLP slab

ParametersUnivariate linear regressionMultiple linear regression
Beta (95% CI)P valueBeta*Beta (95% CI)P value
Per decade in age0.53 (−0.64 to −0.42)0.000.150.34 (−0.46 to −0.22)0.00
Male vs female1.24 (−1.58 to −0.89)0.000.151.01 (−1.32 to −0.70)0.00
Eye-related parameters
 BCVA(LogMAR)5.16 (−6.62 to −3.71)0.00−0.02−0.56 (−1.97 to 0.84)0.43
 Per 1 μm in AL0.48 (−0.60 to −0.35)0.000.180.42 (−0.57 to −0.28)0.00
 Per 1 μm in CCT0.00 (−0.01 to 0.01)1.00
 Per 1 μm in ACD−0.11 (−0.54 to 0.33)0.63
 Per 5 mm Hg in IOP0.08 (−0.25 to 0.40)0.64
 Per 1 dipolar in SE0.10 (0.03 to 0.16)0.000.000.00 (−0.07 to 0.08)0.93
 Per 1 unit in SSI0.21 (0.20 to 0.23)0.000.500.19 (0.17 to 0.20)0.00
Systemic-related parameters
 Per 5 kg/m2 in BMI−0.08 (−0.32 to 0.17)0.54
 Per 5 cm in WC0.15 (−0.24 to −0.07)0.000.040.07 (0.00 to 0.15)0.07
 Prevalent HT0.06 (−0.32 to 0.45)0.74
 Prevalent DM−0.34 (−0.95 to 0.27)0.27
 Per 10 mm Hg in SBP0.29 (−0.39 to −0.20)0.00−0.04−0.07 (−0.19 to 0.05)0.22
 Per 10 mm Hg in DBP0.17 (−0.33 to −0.01)0.030.050.15 (−0.03 to 0.34)0.11
 Per 1 mmol/L in HDL−0.28 (−0.57 to 0.02)0.07
 Per 1 mmol/L in LDL0.00 (−0.20 to 0.20)0.97
 Per 1 mmol/L TG0.01 (−0.10 to 0.12)0.82
 Per 1 μmol/L Creatinine−0.01 (−0.01 to 0.00)0.10
 Per 1% HbA1C−0.18 (−0.40 to 0.03)0.09
 Per 1 mg/L in HsCRP0.01 (−0.03 to 0.04)0.79
Model summary/Adjusted R2=0.39, F=98.23, p=0.00
  • *Standardized beta coefficient.

  • ACD, anterior chamber depth; AL, axial length; BCVA, best corrected visual acuity; BMI, body mass index; BMI, body mass index; CCT, central corneal thickness; DBP, diastolic blood pressure; DM, diabetes mellitus; HbA1C, glycated haemoglobin; HDL, high-density lipoprotein; HsCRP, high-sensitivity C reactive protein; HsCRP, high-sensitivity C reactive protein; HT, hypertension; ILM, internal limiting membrane; IOP, intraocular pressure; LDL, low-density lipoprotein; logMAR, logarithm of the minimum angle of resolution; NFLP, nerve fibre layer plexure, ranging from ILM to outer limit of nerve fibre layer; ;SBP, systolic blood pressure; SE, spherical equivalent; SSI, Signal Strength Index; TG, triglyceride; WC, waist circumference.