Table 5

Cost and consequence comparison of enhanced reference standard* and grader pathway

SensitivitySpecificityCost per 100 patientsCost savings
Standard of care+UWF images*Assumed 100%Assumed 100%£8598
Ophthalmic Grader evaluating UWF images†79.7%58.8%£4263£4335
  • *Ophthalmologists face-to-face evaluation of patients with access to SD-OCT images supplemented by the reading by the ophthalmologists of the UWF images.

  • †In the main analysis, ophthalmic graders refer to ophthalmologists all patients identified as having ‘active PDR’, but also if they were ‘uncertain’ about the diagnosis of if ‘ungradable’ images.

  • UWF, ultrawide field.