Table 1

Summary of reported cases of corneal graft rejection following vaccination

Study	Patient, age, laterality	Eye/episode	Vaccine	Interval postgraft	Type of graft	Interval postvaccination	Outcome
Solomon and Frucht-Pery8	Patient 1, 80, bilateral, simultaneous	OD/first	Influenza (trivalent vaccine for the inactivated strains of A-Beijing-32/92-H3N2, A-Texas-36/91-H1N1 and B-Panama-45/90 of the influenza virus)	11 years	PK	6 weeks	Resolved with topical and sub-Tenon’s steroids and systemic steroids (80 mg prednisolone orally per day).
		OS/first	Influenza (trivalent vaccine for the inactivated strains of A-Beijing-32/92-H3N2, A-Texas-36/91-H1N1 and B-Panama-45/90 of the influenza virus)	8 years	PK	6 weeks and 3 days	Resolved with topical and sub-Tenon’s steroids and systemic steroids (80 mg prednisolone orally per day).
Wertheim et al 7	Patient 2, 67, unilateral	OS/first	Influenza (Sanofi-Pasteur MSD, UK)	8 months	PK	2 weeks	Resolved with topical steroids.
	Patient 3, 67, unilateral, consecutive	OD/first	Influenza (Sanofi-Pasteur MSD, UK)	7 months	PK	3 weeks	Resolved with topical steroids.
		OD/second (1 year after, following annual vaccination)	Influenza	1 year and 7 months	PK	4 weeks	Resolved with topical steroids.
Hamilton et al 10	Patient 4, 33, unilateral	OD/first	Influenza (Fluvax, CSL, Parkville, Victoria, Australia)	2 years and 7 months	DALK	3 weeks	Resolved with topical steroids but residual central stromal haze with visual loss from prior to rejection.
Vignapiano et al 9	Patient 5, 48, unilateral	N/A	Yellow fever	N/A	N/A	3 weeks	Resolved with topical and systemic steroids.

DALK, deep anterior lamellar keratoplasty; N/A, not available; OD, right eye; OS, left eye; PK, penetrating keratoplasty.