Table 3

Areas under receiver operating characteristic curves (AUROCs) for the variables measured using the Laguna ONhE program and OCT-A

	AUROC (95% CI)	P value	Sensitivity at 95% specificity				Sensitivity at 80% specificity
	AUROC (95% CI)	P value	Cut-off	Sensitivity (95% CI)	+LR	−LR	Cut-off	Sensitivity (95% CI)	+LR	−LR
Vessel density
wcpVD	0.93(0.86 to 0.97)	<0.0001	≤17.3	73% (61–83)	14.99	0.28	≤19.9	88% (78–95)	4.51	0.15
wmVD	0.77(0.68 to 0.84)	<0.0001	≤11.6	22% (13–34)	4.59	0.82	≤13.8	60% (47–72)	3.06	0.50
iVD	0.79(0.70 to 0.86)	<0.0001	≤10.4	31% (21–44)	6.43	0.72	≤13.6	55% (43–67)	2.83	0.56
Laguna ONhE
GDF	0.92(0.86 to 0.97)	<0.0001	≤-12.0	75% (63–85)	15.30	0.27	≤-3.7	88% (78–95)	4.51	0.15
Total Hb	0.78(0.69 to 0.85)	<0.0001	≤68.6	42% (30–55)	8.57	0.61	≤69.8	61% (49–73)	3.14	0.48
Cup Hb	0.70(0.60 to 0.78)	0.0002	≤57.3	7% (3–17)	1.53	0.97	≤63.8	45% (33–57)	2.29	0.69
Hb 121–230°	0.67(0.57 to 0.75)	0.0027	≤72.7	16% (8–28)	3.37	0.88	≤74.3	36% (25–49)	1.84	0.80
Hb 231–270°	0.67(0.57 to 0.76)	0.0012	≤73.3	24% (14–36)	4.90	0.80	≤74.9	43% (31–56)	2.22	0.70
Hb 271–310°	0.67 (0.57 to 0.76)	0.0010	≤67.3	25% (16–38)	5.20	0.78	≤69.5	55% (43–67)	2.83	0.56
Hb 311–40° (T)	0.62 (0.52 to 0.71)	0.0432	>69.9	3% (0.4–10)	0.61	1.02	>66.4	28.4% (18–41)	1.45	0.89
Hb 41–80°	0.69 (0.59 to 0.77)	0.0003	≤68.6	24 (14–36)	4.90	0.80	≤70.8	54% (41–66)	2.75	0.57
Hb 81–120°	0.72 (0.63 to 0.81)	<0.0001	≤75.1	43 (31–56)	8.87	0.60	≤76.4	60% (47–72)	3.06	0.50

AUROC, area under the ROC curve; cup Hb, amount of Hb at the optic nerve cup; GDF, glaucoma discriminant function; iVD, papilar vessel density; LR, likelihood ratio; total Hb, total amount of Hb at the ONH; wcpVD, circumpapillary vessel density; wmVD, macular vessel density.