Table 2

Mean 6-month and 1-year changes in visual acuity stratified by diagnosis, follow-up interval and anti-vascular endothelial growth factor injection frequency

Number of anti-VEGF injections
12345678910111213
BRVO 6 months
 No. of patient eyes3546351082169926372049413
 % Patient eyes4%7%12%19%30%23%5%
 Female sex56%55%57%54%55%54%54%
 Mean baseline age (years)72.173.673.271.971.970.770.3
 Mean baseline va (letters)58.859.057.556.754.252.351.9
 Mean VA change (letters)4.52.95.48.010.713.112.7
 P value for change<0.001<0.001<0.001<0.001<0.001<0.001<0.001
 CI (95%)2.65 to 6.411.5 to 4.324.3 to 6.577.08 to 8.899.89 to 11.4612.17 to 13.9510.39 to 14.95
BRVO 1 year
 No. of patient eyes20624135343851669185796494679052129290
 % Patient eyes3%3%5%6%7%10%12%14%14%11%8%4%1%
 Female sex56%56%58%52%58%57%55%57%57%56%53%54%56%
 Mean baseline age (years)72.573.273.072.874.073.672.872.872.170.670.369.570.9
 Mean baseline VA (letters)57.357.659.358.357.356.959.355.056.155.355.253.455.1
 Mean VA change (letters)2.851.764.485.364.826.246.4610.3510.6011.0010.3211.629.03
 P value for change0.0310.114<0.001<0.001<0.001<0.001<0.001<0.001<0.001<0.001<0.001<0.001<0.001
 CI (95%)−0.13 to 5.83−1.09 to 4.62.57 to 6.43.34 to 7.392.97 to 6.674.63 to 7.855.16 to 7.779.01 to 11.79.23 to 11.979.47 to 12.538.34 to 12.38.98 to 14.264.41 to 13.66
CRVO 6 months
 No. of patient eyes203440837131120431567327
 % Patient eyes3%7%12%19%30%23%5%
 Female sex51%55%49%52%50%50%49%
 Mean baseline age (years)72.274.373.473.273.171.371.8
 Mean baseline VA (letters)38.038.738.840.336.635.429.4
 Mean VA change (letters)4.62.12.05.311.714.415.5
 P value for change0.0010.0500.016<0.001<0.001<0.001<0.001
 CI (95%)1.61 to 7.64−0.4 to 4.660.18 to 3.763.74 to 6.7610.42 to 12.8712.91 to 15.912.1 to 18.79
CRVO 1 year
 No. of patient eyes9914423129539451171972478062844623487
 % Patient eyes2%3%4%6%7%10%14%14%15%12%8%4%2%
 Female sex60%53%48%54%53%48%51%49%53%51%47%48%43%
 Mean baseline age (years)75.271.673.474.473.773.873.773.372.771.971.169.772.1
 Mean baseline VA (letters)29.939.237.937.842.241.339.842.239.238.336.937.743.5
 Mean VA change (letters)4.35.1−0.22.01.93.05.17.310.911.111.715.27.7
 P alue for change0.0430.0130.4500.1340.0990.014<0.001<0.001<0.001<0.001<0.001<0.001<0.001
 CI (95%)−0.56 to 9.130.66 to 9.48−3.84 to 3.38−1.52 to 5.48−1.01 to 4.90.34 to 5.662.88 to 7.365.16 to 9.418.68 to 13.098.62 to 13.518.74 to 14.5711.2 to 19.22.83 to 12.5
  • BRVO, branch retinal vein occlusion; CRVO, central retinal vein occlusion; VA, visual acuity; VEGF, vascular endothelial growth factor.