Table 1

Baseline features and outcomes

Stratified by diagnosis and follow-up interval
BRVO
6 months
BRVO
1 year
CRVO
6 months
CRVO
1 year
No. of patient eyes8876691467375300
Female sex55%56%51%51%
Mean baseline age (years)71.872.372.872.9
Mean baseline VA
 Letters55.156.637.239.5
 Snellen equivalent20/8020/8020/20020/160
Initial anti-VEGF agent
 Bevacizumab49%49%48%46%
 Aflibercept14%14%20%21%
 Ranibizumab36%37%32%33%
Mean no. of anti-VEGF injections4.57.44.67.6
Median no. of anti-VEGF injections5858
Other treatments
 Steroid injections, mean #0.060.150.060.17
  Steroid injections, % patients5%9%8%9%
 Focal laser, mean #0.070.130.010.03
  Focal laser, % patients7%12%1%2%
 Panretinal laser, mean #0.020.030.040.09
  Panretinal laser, % patients2%3%5%6%
Mean VA change ( letters)9.48.19.27.1
 P value for change<0.001<0.001<0.001<0.001
 CI (95%)8.94 to 9.787.55 to 8.578.50 to 9.876.31 to 7.95
Stratified by diagnosis, follow-up interval and baseline visual acuity
20/40 or better20/40–20/7020/70–20/20020/200 or worse
BRVO 6 months
 No. of patient eyes2428294624421060
 % Patient eyes27%33%28%12%
 Female sex53%55%55%59%
 Mean baseline age (years)69.372.272.973.9
 Mean no. of anti-VEGF injections4.34.54.64.8
 Mean VA change (letters)−0.25.212.934.6
  P value for change0.318<0.001<0.001<0.001
  CI (95%)−0.53 to 0.174.77 to 5.6412.22 to 13.6132.51 to 36.69
BRVO 1 year
 No. of patient eyes204123631786715
 % Patient eyes30%34%26%10%
 Female sex53%55%58%61%
 Mean baseline age (years)70.072.773.873.7
 Mean no. of anti-VEGF injections7.07.47.57.5
 Mean VA change (letters)−1.34.212.037.6
  P value for change<0.001<0.001<0.001<0.001
  CI (95%)−1.76 to −0.813.64 to 4.7911.02 to 12.8935.02 to 40.21
CRVO 6 months
 No. of patient eyes954162019952167
 % Patient eyes14%24%30%32%
 Female sex47%50%49%53%
 Mean baseline age (years)68.771.973.074.9
 Mean no. of anti-VEGF injections4.34.54.64.7
 Mean VA change (letters)−4.50.37.023.9
  P value for change<0.0010.529<0.001<0.001
  CI (95%)−5.6 to −3.45−0.68 to 1.285.91 to 8.0422.41 to 25.37
CRVO 1 year
 No. of patient eyes768137215771575
 % Patient eyes15%26%30%30%
 Female sex47%51%49%53%
 Mean baseline age (years)70.072.472.974.7
 Mean no. of anti-VEGF injections7.27.67.97.6
 Mean VA change (letters)−5.8−2.36.022.9
  P value for change<0.001<0.001<0.001<0.001
  CI (95%)−7.16 to −4.49−3.59 to −1.114.65 to 7.3121.09 to 24.71
  • BRVO, branch retinal vein occlusion; CRVO, central retinal vein occlusion; VA, visual acuity; VEGF, vascular endothelial growth factor.