Table 2

Stage IV uveal melanoma at initial presentation (group M)

AJCC tumour categoryChoroidal n=55Ciliary body n=11Iris n=3Total n=69
T-category T1aNo CBI/ESE4 (7%)0 (0%)0 (0%)4 (6%)
T1bCBI only0 (0%)1 (9%)2 (67%)3 (4%)
T1cESE only (≤5 mm)1 (2%)0 (0%)0 (0%)1 (1%)
T1dBoth CBI and ESE (≤5 mm)0 (0%)0 (0%)0 (0%)0 (0%)
T2aNo CBI/ESE17 (31%)0 (0%)0 (0%)17 (26%)
T2bCBI only0 (0%)2 (18%)0 (0%)2 (3%)
T2cESE only (≤5 mm)1 (2%)0 (0%)0 (0%)1 (1%)
T2dBoth CBI and ESE (≤5 mm)0 (0%)0 (0%)0 (0%)0 (0%)
T3aNo CBI/ESE13 (27%)0 (0%)0 (0%)13 (19%)
T3bCBI only2 (4%)3 (27%)0 (0%)5 (7%)
T3cESE only (≤5 mm)0 (0%)0 (0%)0 (0%)0 (0%)
T3dBoth CBI and ESE (≤5 mm)1 (2%)4 (36%)0 (0%)5 (7%)
T4aNo CBI/ESE8 (14%)0 (0%)1 (33%)9 (13%)
T4bCBI only5 (9%)0 (0%)0 (0%)5 (7%)
T4cESE only (≤5 mm)0 (0%)0 (0%)0 (0%)0 (0%)
T4dBoth CBI and ESE (≤5 mm)2 (4%)0 (0%)0 (0%)2 (3%)
T4eESE (>5 mm)1 (2%)1 (9%)0 (0%)2 (3%)
Metastasis sites Regional lymph nodes (N1a)5 (9%)4 (36%)0 (0%)9 (13%)
Liver38 (69%)9 (82%)3 (100%)50 (72%)
Lung3 (5%)0 (0%)0 (0%)3 (4%)
Bone0 (0%)0 (0%)0 (0%)0 (0%)
Brain0 (0%)0 (0%)0 (0%)(0%)
Subcutaneous tissue0 (0%)0 (0%)0 (0%)0 (0%)
Other sites0 (0%)0 (0%)0 (0%)0 (0%)
Multiple sites14 (26%)2 (18%)0 (0%)16 (24%)
  • AJCC, American Joint Committee on Cancer, 8th edition; CBI, ciliary body involvement; ESE, extrascleral extension.