Table 2

Mean difference in intraocular pressure at 3 months (95% credible interval) derived from the NMA

Placebo−5.39−5.59−4.72−5.42−5.00−1.97−2.86−2.53−3.66−2.53−3.24−2.55−4.79−3.73−4.84
(−6.60 to −4.21)(−6.43 to−4.75)(−5.39 to−4.04)(−6.68 to−4.16)(−6.15 to−3.88)(−2.88 to−1.06)(−4.65 to−1.12)(−3.32 to−1.75)(−4.48 to−2.85)(−3.52 to−1.56)(−4.40 to−2.09)(−3.33 to−1.78)(−5.64 to−3.95)(−4.36 to−3.10)(−5.69 to−3.98)
5.39 Bimatoprost 0.01% −0.200.67−0.020.39 3.42 2.53 2.86 1.73 2.85 2.15 2.84 0.60 1.66 0.55
(4.21 to 6.60)(−1.41 to1.03)(−0.44 to1.80)(−1.59 to1.55)(−1.06 to1.82)(2.11 to 4.75)(0.51 to 4.51)(1.59 to 4.15)(0.47 to 2.99)(1.45 to 4.27)(0.65 to 3.65)(1.55 to 4.13)(−0.70 to1.92)(0.52 to 2.81)(−0.60 to1.72)
5.59 0.20 Bimatoprost 0.03% 0.88 0.170.59 3.62 2.73 3.06 1.93 3.06 2.35 3.04 0.80 1.86 0.75
(4.75 to 6.43)(−1.03 to1.41)(0.26 to 1.48)(−1.07 to1.42)(−0.54 to1.69)(2.69 to 4.55)(0.94 to 4.47)(2.18 to 3.95)(1.09 to 2.76)(2.01 to 4.10)(1.18 to 3.50)(2.12 to 3.94)(−0.12 to1.71)(1.24 to 2.48)(0.08 to 1.43)
4.72 −0.67−0.88 Latanoprost −0.70−0.29 2.75 1.85 2.18 1.05 2.18 1.47 2.17 −0.08 0.99 −0.12
(4.04 to 5.39)(−1.80 to0.44)(−1.48 to−0.26)(−1.83 to0.43)(−1.28 to0.69)(2.01 to 3.49)(0.13 to 3.53)(1.46 to 2.92)(0.41 to 1.69)(1.27 to 3.09)(0.41 to 2.53)(1.41 to 2.92)(−0.85 to0.70)(0.58 to 1.39)(−0.75 to0.52)
5.42 0.02−0.170.70 Latanoprostene Bunod 0.41 3.45 2.55 2.89 1.75 2.88 2.17 2.87 0.62 1.69 0.58
(4.16 to 6.68)(−1.55 to1.59)(−1.42 to1.07)(−0.43 to1.83)(−1.07 to1.87)(2.12 to 4.77)(0.55 to 4.52)(1.60 to 4.17)(0.49 to 3.02)(1.47 to 4.29)(0.69 to 3.65)(1.55 to 4.17)(−0.68 to1.92)(0.58 to 2.80)(−0.69 to1.85)
5.00 −0.39−0.590.29−0.41 Tafluprost 3.04 2.14 2.47 1.34 2.47 1.76 2.46 0.21 1.28 0.17
(3.88 to 6.15)(−1.82 to1.06)(−1.69 to0.54)(−0.69 to1.28)(−1.87 to1.07)(1.83 to 4.25)(0.20 to 4.05)(1.31 to 3.66)(0.21 to 2.49)(1.18 to 3.77)(0.38 to 3.15)(1.27 to 3.65)(−0.97 to1.41)(0.30 to 2.27)(−0.92 to1.28)
1.97 −3.42 −3.62 −2.75 −3.45 −3.04 Unoprostone −0.90−0.56−1.70 −0.57−1.28 −0.58−2.82 −1.76 −2.87
(1.06 to 2.88)(−4.75 to−2.11)(−4.55 to−2.69)(−3.49 to−2.01)(−4.77 to−2.12)(−4.25 to−1.83)(−2.73 to0.90)(−1.50 to0.38)(−2.63 to−0.75)(−1.69 to0.56)(−2.52 to−0.03)(−1.57 to0.41)(−3.83 to−1.81)(−2.53 to−0.99)(−3.82 to−1.92)
2.86 −2.53 −2.73 −1.85 −2.55 −2.14 0.90 Apraclonidine 0.33−0.800.33−0.380.31−1.93 −0.86−1.98
(1.12 to 4.65)(−4.51 to−0.51)(−4.47 to−0.94)(−3.53 to−0.13)(−4.52 to−0.55)(−4.05 to−0.20)(−0.90 to2.73)(−1.43 to2.14)(−2.54 to0.99)(−1.51 to2.21)(−2.28 to1.54)(−1.46 to2.13)(−3.70 to−0.13)(−2.49 to0.81)(−3.73 to−0.18)
2.53 −2.86 −3.06 −2.18 −2.89 −2.47 0.56−0.33 Betaxolol −1.13 0.00−0.71−0.02−2.26 −1.20 −2.31
(1.75 to 3.32)(−4.15 to−1.59)(−3.95 to−2.18)(−2.92 to−1.46)(−4.17 to−1.60)(−3.66 to−1.31)(−0.38 to1.50)(−2.14 to1.43)(−1.99 to−0.29)(−1.06 to1.03)(−1.90 to0.46)(−0.87 to0.81)(−3.17 to−1.37)(−1.88 to−0.52)(−3.21 to−1.40)
3.66 −1.73 −1.93 −1.05 −1.75 −1.34 1.70 0.80 1.13 Brimonidine 1.13 0.42 1.11 −1.13 −0.06−1.17
(2.85 to 4.48)(−2.99 to−0.47)(−2.76 to−1.09)(−1.69 to−0.41)(−3.02 to−0.49)(−2.49 to−0.21)(0.75 to 2.63)(−0.99 to2.54)(0.29 to 1.99)(0.21 to 2.04)(−0.75 to1.59)(0.23 to 1.99)(−2.05 to−0.21)(−0.70 to0.57)(−2.02 to−0.32)
2.53 −2.85 −3.06 −2.18 −2.88 −2.47 0.57−0.330.00−1.13 Brinzolamide −0.71−0.01−2.26 −1.19−2.30
(1.56 to 3.52)(−4.27 to−1.45)(−4.10 to−2.01)(−3.09 to−1.27)(−4.29 to−1.47)(−3.77 to−1.18)(−0.56 to1.69)(−2.21 to1.51)(−1.03 to1.06)(−2.04 to−0.21)(−2.01 to0.60)(−0.99 to0.95)(−3.34 to−1.17)(−2.06 to−0.32)(−3.36 to−1.24)
3.24 −2.15 −2.35 −1.47 −2.17 −1.76 1.28 0.380.71−0.420.71 Carteolol 0.69−1.55 −0.48−1.59
(2.09 to 4.40)(−3.65 to−0.65)(−3.50 to−1.18)(−2.53 to−0.41)(−3.65 to−0.69)(−3.15 to−0.38)(0.03 to 2.52)(−1.54 to2.28)(−0.46 to1.90)(−1.59 to0.75)(−0.60 to2.01)(−0.51 to1.89)(−2.68 to−0.42)(−1.46 to0.50)(−2.76 to−0.42)
2.55 −2.84 −3.04 −2.17 −2.87 −2.46 0.58−0.310.02−1.11 0.01−0.69 Dorzolamide −2.24 −1.18 −2.29
(1.78 to 3.33)(−4.13 to−1.55)(−3.94 to−2.12)(−2.92 to−1.41)(−4.17 to−1.55)(−3.65 to−1.27)(−0.41 to1.57)(−2.13 to1.46)(−0.81 to0.87)(−1.99 to−0.23)(−0.95 to0.99)(−1.89 to0.51)(−3.18 to−1.29)(−1.88 to−0.47)(−3.21 to−1.35)
4.79 −0.60−0.800.08−0.62−0.21 2.82 1.93 2.26 1.13 2.26 1.55 2.24 Levobunolol 1.06 −0.05
(3.95 to 5.64)(−1.92 to0.70)(−1.71 to0.12)(−0.70 to0.85)(−1.92 to0.68)(−1.41 to0.97)(1.81 to 3.83)(0.13 to 3.70)(1.37 to 3.17)(0.21 to 2.05)(1.17 to 3.34)(0.42 to 2.68)(1.29 to 3.18)(0.38 to 1.75)(−0.98 to0.89)
3.73 −1.66 −1.86 −0.99 −1.69 −1.28 1.76 0.86 1.20 0.06 1.19 0.48 1.18 −1.06 Timolol −1.11
(3.10 to 4.36)(−2.81 to−0.52)(−2.48 to−1.24)(−1.39 to−0.58)(−2.80 to−0.58)(−2.27 to−0.30)(0.99 to 2.53)(−0.81 to2.49)(0.52 to 1.88)(−0.57 to0.70)(0.32 to 2.06)(−0.50 to1.46)(0.47 to 1.88)(−1.75 to−0.38)(−1.76 to−0.46)
4.84 −0.55−0.75 0.12−0.58−0.17 2.87 1.98 2.31 1.17 2.30 1.59 2.29 0.05 1.11 Travoprost
(3.98 to 5.69)(−1.72 to0.60)(−1.43 to−0.08)(−0.52 to0.75)(−1.85 to0.69)(−1.28 to0.92)(1.92 to 3.82)(0.18 to 3.73)(1.40 to 3.21)(0.32 to 2.02)(1.24 to 3.36)(0.42 to 2.76)(1.35 to 3.21)(−0.89 to0.98)(0.46 to1.76)

  • Embedded Image, PGA

  • Embedded Image, others

  • Results presented in bold are significant.

  • Mean difference under 0 favours the drug in the column.

  • NAM, network meta-analysis; PGA, prostaglandin analogue.