Table 2

Comparison of carrier and allele frequencies of HLA subtypes between patients with SJS/TEN developing SOCs and normal controls

HLA subtypeCarrier frequencyAllele frequency
CaseControlP valueOR
(95% CI)
CaseControlP valueOR
(95% Cl)
FisherBonferroni correctionFisherBonferroni correction
A*02:067.7%
(2/26)
5.1%
(5/98)
0.6363.9%
(2/52)
3.1%
(6/196)
0.675
A*02:0726.9%
(6/26)
10.2%
(10/98)
0.049 0.487 3.24(1.09 to9.60)17.3%
(9/52)
5.1%
(10/196)
0.007 0.068 3.89(1.49to 10.16)
A*11:0134.6%
(9/26)
55.1%
(54/98)
0.07921.2%
(11/52)
31.6%
(62/196)
0.172
B*46:0130.8%
(8/26)
19.4%
(19/98)
0.28419.2%
(10/52)
10.2%
(20/196)
0.093
  • Bold type denotes p values with significance.

  • HLA, human leucocyte antigen; SJS, Stevens-Johnson syndrome; SOCs, severe ocular complications; TEN, toxic epidermal necrolysis.