Comparison of carrier and allele frequencies of HLA subtypes between patients with SJS/TEN developing SOCs and normal controls
| HLA subtype | Carrier frequency | Allele frequency | ||||||||
| Case | Control | P value | OR (95% CI) | Case | Control | P value | OR (95% Cl) | |||
| Fisher | Bonferroni correction | Fisher | Bonferroni correction | |||||||
| A*02:06 | 7.7% (2/26) | 5.1% (5/98) | 0.636 | 3.9% (2/52) | 3.1% (6/196) | 0.675 | ||||
| A*02:07 | 26.9% (6/26) | 10.2% (10/98) | 0.049 | 0.487 | 3.24(1.09 to9.60) | 17.3% (9/52) | 5.1% (10/196) | 0.007 | 0.068 | 3.89(1.49to 10.16) |
| A*11:01 | 34.6% (9/26) | 55.1% (54/98) | 0.079 | 21.2% (11/52) | 31.6% (62/196) | 0.172 | ||||
| B*46:01 | 30.8% (8/26) | 19.4% (19/98) | 0.284 | 19.2% (10/52) | 10.2% (20/196) | 0.093 | ||||
Bold type denotes p values with significance.
HLA, human leucocyte antigen; SJS, Stevens-Johnson syndrome; SOCs, severe ocular complications; TEN, toxic epidermal necrolysis.