Table 1

Baseline demographic characteristics and Angio 3×3 mm vessel density metrics considering distinct DRSS stages of the disease

Demographics		Healthy	ETDRS 10	ETDRS 20	ETDRS 35	ETDRS 43	ETDRS 47–53
N		38	16	18	39	17	15
Age (years)		65.8±10.2	68.8±4.8	64.8±7.0	66.9±9.5	66.6±7.9	65.4±7.5
Sex (Male/female)		20/18	9/7	10/8	28/11	13/4	10/5
Diabetes duration (years)		–	18.5±11.3	20.8±13.8	21.6±10.7	21.7±5.9	16.2±8.8
HbA1c (%)		6.2±1.0	7.1±1.1	7.4±1.3	77.6±0.8	7.5±1.3	8.1±1.1
BCVA (letters)		83.0±4.3	83.4±4.4	84.3±6.3	84.2±4.5	82.4±6.8	80.1±8.0
Vessel density SCPm mm^-1	(Inner ring (5. 10)°)	14.7±1.3	12.6±2.5 p=0.009	13.2±1.7 p=0.005	12.1±2.0 p=0.000	12.2±1.9 p=0.010	12.0±1.3 p=0.001
Vessel density DCP, mm-1	(Inner ring (5. 10)°)	14.5±1.5	11.9±2.8 p=0.003	13.0±1.6 p=0.012	12.9±2.3 p=0.014	12.3±2.5 p=0.045	11.6±1.2 p=0.001
Vessel density FR, mm^-1	(Inner ring (5. 10)°)	17.9±1.1	15.7±2.8 p=0.009	16.6±1.3 p=0.008	16.0±2.0 p=0.000	15.4±2.0 p=0.010	15.2±1.4 p=0.000
Thickness retina, µm	(Central SF (0. 5)°)	271.4±20.6	276.3±29.6 p=0.675	277.4±38.3 p=0.952	282.2±29.0 p=0.201	274.8±23.4 p=0.677	305.0±49.6 p=0–132
Thickness retina, µm	(Inner ring (5. 10)°)	332.8±17.7	330.1±12.7 p=0.646	331.7±14.5 p=0.971	328.1±17.2 p=0.509	333.4±17.8 p=0.850	346.3±30.3 p=0.338

Vessel density values, obtained using PlexElite 3 mm×3 mm, and retinal thickeness values were calculated using Zeiss MultiLayer segmentation algorithm. Comparisons between diabetic individuals and healthy controls were performed using Mann-Whitney U-test. Bonferroni correction was applied to vessel density comparisons setting the statistical significance to p<0.0167, otherwise p<0.05.
Data are presented as mean±SD.
Statistical significance highlighted in bold.
BCVA, best corrected visual acuity; DCP, deep capillary plexus; FR, full retina; HbA1c, glycated haemoglobin; SCP, superficial capillary plexus.