Table 2

Gene signalling pathway in each experimental group

	PI3K-Akt pathway genes*	P value	RAS pathway genes*	P value	PPARγ pathway genes*	P value	Adipocytokine pathway genes*	P value	AMPK pathway genes*	P value
TAO	27	0.049	22	0.010	9	0.026	11	0.004	16	0.002
GPA	41	0.001	28	0.005	13	0.002	13	0.004	26	<0.001
Sarcoidosis	105	<0.001	71	0.001	22	0.001	23	0.048	44	0.001
NSOI	50	0.043	38	0.006	16	0.006	16	0.009	26	0.002

*Number of significantly enriched genes belonging to the pathway compared with normal.
AMPK, adenosine monophosphate-activated protein kinase; GPA, granulomatosis with polyangiitis; NSOI, non-specific orbital inflammation; PPARγ, peroxisome proliferator-activated receptor-γ; TAO, thyroid-associated orbitopathy.