Mixed model analysis of OCT and OCTA parameters associated with logMAR visual acuity (VA) based on glaucoma severity
| Variables | Early glaucoma | Moderate-advanced glaucoma | ||||||||||
| Superficial VD (per 1% lower) | Deep VD (per 1% lower) | GCC thickness (per 1 um thinner) | Superficial VD (per 1% lower) | Deep VD (per 1% lower) | GCC thickness (per 1 um thinner) | |||||||
| β, 95% CI | P value | β, 95 % CI | P value | β, 95% CI | P value | β, 95% CI | P value | β, 95% CI | P value | β, 95% CI | P value | |
| Corrected FAZ area, per 0.1 mm2 increase | 0.006 (−0.013 to 0.025) | 0.533 | 0.023 (0.002 to 0.043) | 0.035 | ||||||||
| FAZ circumference, per 1 mm increase | 0.016 (−0.025 to 0.058) | 0.437 | 0.063 (0.006 to 0.120) | 0.032 | ||||||||
| FD300 | 0.002 (−0.002 to 0.005) | 0.250 | 0.001 (−0.004 to 0.006) | 0.676 | ||||||||
| Foveal | 0.001 (−0.002 to 0.003) | 0.626 | 0.002 (−0.000 to 0.004) | 0.060 | 0.001 (−0.002 to 0.003) | 0.552 | 0.002 (−0.001 to 0.005) | 0.167 | 0.004 (0.000 to 0.007) | 0.049 | 0.003 (0.002 to 0.005) | 0.001 |
| Parafoveal | 0.002 (−0.001 to 0.006) | 0.163 | 0.003 (−0.002 to 0.007) | 0.308 | 0.001 (−0.001 to 0.002) | 0.502 | 0.005 (−0.002 to 0.012) | 0.160 | 0.002 (−0.007 to 0.015) | 0.634 | 0.003 (0.001 to 0.004) | <0.001 |
| Superior hemifield | 0.003 (−0.001 to 0.007) | 0.180 | 0.004 (−0.002 to 0.010) | 0.210 | 0.001 (−0.001 to 0.003) | 0.382 | 0.007 (−0.000 to 0.014) | 0.061 | 0.003 (−0.007 to 0.013) | 0.516 | 0.003 (0.001 to 0.005) | <0.001 |
| Inferior hemifield | 0.001 (−0.001 to 0.004) | 0.253 | 0.003 (−0.004 to 0.005) | 0.897 | 0.000 (−0.001 to 0.002) | 0.693 | 0.002 (−0.004 to 0.008) | 0.566 | 0.001 (−0.007 to 0.008) | 0.889 | 0.002 (0.001 to 0.003) | 0.012 |
| Perifoveal | 0.001 (−0.004 to 0.006) | 0.778 | 0.003 (−0.002 to 0.007) | 0.238 | −0.001 (−0.004 to 0.002) | 0.386 | 0.006 (−0.001 to 0.013) | 0.090 | 0.006 (−0.001 to 0.013) | 0.115 | 0.002 (0.001 to 0.005) | 0.015 |
| Superior hemifield | 0.001 (−0.005 to 0.006) | 0.770 | 0.003 (−0.001 to 0.008) | 0.154 | −0.001 (−0.004 to 0.002) | 0.491 | 0.007 (0.000 to 0.014) | 0.045 | 0.006 (−0.002 to 0.013) | 0.120 | 0.003 (0.001 to 0.005) | 0.001 |
| Inferior hemifield | 0.000 (−0.004 to 0.005) | 0.822 | 0.001 (−0.003 to 0.006) | 0.523 | −0.001 (−0.003 to 0.001) | 0.366 | 0.003 (−0.002 to 0.009) | 0.224 | 0.003 (−0.003 to 0.009) | 0.260 | 0.001 (−0.001 to 0.003) | 0.284 |
| Whole-image | 0.001 (−0.004 to 0.006) | 0.628 | 0.002 (−0.003 to 0.007) | 0.371 | −0.001 (−0.004 to 0.001) | 0.336 | 0.006 (−0.001 to 0.014) | 0.099 | 0.007 (−0.001 to 0.015) | 0.090 | 0.003 (0.001 to 0.005) | 0.008 |
| Superior hemifield | 0.002 (−0.004 to 0.007) | 0.582 | 0.003 (−0.002 to 0.008) | 0.232 | −0.001 (−0.004 to 0.002) | 0.549 | 0.008 (0.000 to 0.016) | 0.042 | 0.007 (−0.002 to 0.015) | 0.119 | 0.003 (0.001 to 0.005) | 0.001 |
| Inferior hemifield | 0.001 (−0.003 to 0.005) | 0.690 | 0.001 (−0.003 to 0.006) | 0.538 | −0.001 (−0.003 to 0.001) | 0.283 | 0.003 (−0.003 to 0.009) | 0.273 | 0.005 (−0.002 to 0.011) | 0.160 | 0.001 (−0.001 to 0.003) | 0.195 |
Values are shown in β coefficient (95% CI). A positive β coefficient indicated worse logMAR VA. Statistically significant p values are shown in bold.
All models were adjusted for age and signal strength index. The FAZ area was additionally adjusted for axial length.
FAZ, foveal avascular zone; FD300, foveal density 300; GCC, ganglion cell complex; LogMAR VA, Logarithm of the Minimum Angle of Resolution Visual Acuity; OCT, optical coherence tomography; OCTA, OCT angiography; POAG, primary open-angle glaucoma; VD, vessel density.