Table 3

Receiver operating characteristic analysis of the discriminative power of OCT/OCTA parameters to detect decreased visual acuity

VariablesEarly glaucomaModerate-advanced glaucoma
Superficial VDDeep VDGCC thicknessSuperficial VDDeep VDGCC thickness
AUC95% CIAUC95% CIAUC95% CIAUC95% CIAUC95% CIAUC95% CI
Corrected FAZ area0.72(0.50 to 0.90)0.66(0.52 to 0.80)
FAZ circumference0.65(0.39 to 0.92)0.67(0.53 to 0.81)
FD3000.67(0.45 to 090)0.66(0.52 to 0.80)
Foveal0.71(0.49 to 0.92)0.72(0.50 to 0.93)0.73(0.54 to 0.93)0.65(0.51 to 0.79)0.66(0.51 to 0.80)0.79(0.68 to 0.90)
Parafoveal0.74(0.53 to 0.95)0.73(0.52 to 0.94)0.75(0.55 to 0.94)0.71(0.58 to 0.83)0.70(0.55 to 0.85)0.80(0.68 to 0.91)
 Superior hemifield0.75(0.53 to 0.97)0.74(0.54 to 0.94)0.76(0.54 to 0.97)0.72(0.59 to 0.85)0.65(0.51 to 0.79)0.81(0.69 to 0.92)
 Inferior hemifield0.73(0.53 to 0.93)0.71(0.48 to 0.93)0.72(0.52 to 0.93)0.67(0.54 to 0.81)0.68(0.52 to 0.83)0.75(0.62 to 0.88)
Perifoveal0.70(0.48 to 0.91)0.74(0.53 to 0.94)0.67(0.44 to 0.91)0.67(0.54 to 0.81)0.69(0.55 to 0.83)0.68(0.55 to 0.82)
 Superior hemifield0.71(0.47 to 0.94)0.75(0.54 to 0.95)0.68(0.45 to 0.91)0.71(0.58 to 0.84)0.70(0.56 to 0.83)0.71(0.58 to 0.84)
 Inferior hemifield0.68(0.45 to 0.91)0.72(0.50 to 0.93)0.68(0.44 to 0.91)0.63(0.50 to 0.77)0.66(0.51 to 0.80)0.64(0.50 to 0.78)
Whole image0.73(0.53 to 0.93)0.72(0.52 to 0.92)0.72(0.50 to 0.93)0.68(0.55 to 0.82)0.70(0.56 to 0.84)0.68(0.55 to 0.82)
 Superior hemifield0.73(0.52 to 0.94)0.77(0.59 to 0.96)0.68(0.44 to 0.92)0.71(0.58 to 0.84)0.71(0.57 to 084)0.73(0.60 to 0.86)
 Inferior hemifield0.70(0.49 to 0.92)0.71(0.49 to 0.92)0.71(0.48 to 0.93)0.65(0.52 to 0.79)0.68(0.54 to 0.82)0.64(0.51 to 0.78)
  • All models were adjusted for age and Signal Strength Index. The FAZ area was additionally adjusted for axial length.

  • AUC, area under the curve; FAZ, foveal avascular zone; FD300, foveal density 300; GCC, ganglion cell complex; OCT, optical coherence tomography; OCTA, OCT angiography; VD, vessel density.