Demographics and baseline clinical characteristics of the subjects
| Characteristic | POAG eyes (n=144 eyes of 100 patients) | P value | |
| Early glaucoma | Moderate-advanced glaucoma | ||
| n=80 eyes of 62 patients | n=64 eyes of 53 patients | ||
| Age (years) | 78.7 (76.7 to 80.6) | 79.8 (77.8 to 81.7) | 0.213 |
| Gender (female/male) | 34/28 | 25/28 | 0.697 |
| Race (African American/non-African American) | 12/50 | 8/45 | 0.635 |
| Hypertension (hypertensive/non-hypertensive) | 38/24 | 36/17 | 0.303 |
| Diabetes (diabetic/non-diabetic) | 7/55 | 9/44 | 0.412 |
| IOP (mm Hg) | 14.6 (13.5 to 15.6) | 13.2 (11.6 to 14.5) | 0.089 |
| VF MD (dB) | −2.7 (−3.1 to –2.3) | −13.4 (−14.5 to –11.5) | <0.001 |
| VF PSD (dB) | 4.0 (3.5 to 4.5) | 9.7 (9.0 to 10.4) | <0.001 |
| LogMAR VA | 0.05 (0.03 to 0.07) | 0.11 (0.08 to 0.13) | 0.003 |
| Decreased VA (n, [%]) | 9 (11) | 24 (38) | <0.001 |
| Corrected FAZ area (mm2) | 0.30 (0.27 to 0.33) | 0.30 (0.27 to 0.33) | 0.979 |
| FAZ circumference (mm) | 2.06 (1.94 to 2.17) | 2.10 (1.99 to 2.21) | 0.661 |
| FD300 (%) | 49.2 (47.8 to 50.5) | 45.8 (44.2 to 47.4) | 0.003 |
| fGCC (µm) | 53.0 (50.4 to 55.6) | 49.0 (45.6 to 52.4) | 0.055 |
| pfGCC (µm) | 87.5 (84.6 to 90.5) | 79.1 (75.2 to 83.0) | 0.001 |
| perifGCC (µm) | 79.9 (77.7 to 82.0) | 74.1 (71.4 to 76.7) | 0.001 |
| wiGCC (µm) | 81.0 (78.9 to 83.1) | 74.7 (72.1 to 77.3) | <0.001 |
| Superficial fVD (%) | 17.6 (16.0 to 19.1) | 18.0 (16.0 to 19.9) | 0.803 |
| Superficial pfVD (%) | 43.8 (42.6 to 45.0) | 40.5 (39.2 to 41.8) | 0.002 |
| Superficial perifVD (%) | 40.2 (39.3 to 41.1) | 36.0 (34.9 to 37.1) | <0.001 |
| Superficial wiVD (%) | 40.1 (39.3 to 41.0) | 36.2 (35.1 to 37.3) | <0.001 |
| Deep fVD (%) | 32.7 (30.8 to 34.5) | 31.6 (29.7 to 33.5) | 0.489 |
| Deep pfVD (%) | 50.0 (49.0 to 51.1) | 47.4 (46.2 to 48.5) | 0.003 |
| Deep perifVD (%) | 44.5 (43.3 to 45.8) | 41.3 (39.8 to 42.7) | 0.003 |
| Deep wiVD (%) | 44.1 (42.9 to 45.2) | 41.1 (39.8 to 42.4) | 0.003 |
| OCT/OCTA SSI | 59.0 (57.5 to 60.5) | 57.4 (55.9 to 58.9) | 0.192 |
Values are shown in mean (95% CI), unless otherwise indicated. Statistically significant P values are shown in bold.
f, foveal; FAZ, foveal avascular zone; FD300, foveal density 300; GCC, ganglion cell complex; IOP, intraocular pressure; MD, mean deviation; OCT, optical coherence tomography; OCTA, OCT angiography; perif, perifoveal; pf, parafoveal; POAG, primary open-angle glaucoma; PSD, pattern SD; SSI, Signal Strength Index; VA, visual acuity; VD, vessel density; VF, visual field; wi, whole-image.