Table 3

The univariate and multiple regression analysis of whole image vessel density at NFLP slab

Parameters	Univariate linear regression		Multiple linear regression
Parameters	Beta (95% CI)	P value	Beta*	Beta (95% CI)	P value
Per decade in age	− *0.53 (−0.64 to −0.42)*	*0.00*	− *0.15*	− *0.34 (−0.46 to −0.22)*	*0.00*
Male vs female	− *1.24 (−1.58 to −0.89)*	*0.00*	− *0.15*	− *1.01 (−1.32 to −0.70)*	*0.00*
Eye-related parameters
BCVA(LogMAR)	− *5.16 (−6.62 to −3.71)*	*0.00*	−0.02	−0.56 (−1.97 to 0.84)	0.43
Per 1 μm in AL	− *0.48 (−0.60 to −0.35)*	*0.00*	− *0.18*	− *0.42 (−0.57 to −0.28)*	*0.00*
Per 1 μm in CCT	0.00 (−0.01 to 0.01)	1.00
Per 1 μm in ACD	−0.11 (−0.54 to 0.33)	0.63
Per 5 mm Hg in IOP	0.08 (−0.25 to 0.40)	0.64
Per 1 dipolar in SE	*0.10 (0.03 to 0.16)*	*0.00*	0.00	0.00 (−0.07 to 0.08)	0.93
Per 1 unit in SSI	*0.21 (0.20 to 0.23)*	*0.00*	*0.50*	*0.19 (0.17 to 0.20)*	*0.00*
Systemic-related parameters
Per 5 kg/m² in BMI	−0.08 (−0.32 to 0.17)	0.54
Per 5 cm in WC	− *0.15 (−0.24 to −0.07)*	*0.00*	0.04	0.07 (0.00 to 0.15)	0.07
Prevalent HT	0.06 (−0.32 to 0.45)	0.74
Prevalent DM	−0.34 (−0.95 to 0.27)	0.27
Per 10 mm Hg in SBP	− *0.29 (−0.39 to −0.20)*	*0.00*	−0.04	−0.07 (−0.19 to 0.05)	0.22
Per 10 mm Hg in DBP	− *0.17 (−0.33 to −0.01)*	*0.03*	0.05	0.15 (−0.03 to 0.34)	0.11
Per 1 mmol/L in HDL	−0.28 (−0.57 to 0.02)	0.07
Per 1 mmol/L in LDL	0.00 (−0.20 to 0.20)	0.97
Per 1 mmol/L TG	0.01 (−0.10 to 0.12)	0.82
Per 1 μmol/L Creatinine	−0.01 (−0.01 to 0.00)	0.10
Per 1% HbA1C	−0.18 (−0.40 to 0.03)	0.09
Per 1 mg/L in HsCRP	0.01 (−0.03 to 0.04)	0.79
Model summary	/		Adjusted R²=0.39, F=98.23, p=0.00

*Standardized beta coefficient.
ACD, anterior chamber depth; AL, axial length; BCVA, best corrected visual acuity; BMI, body mass index; BMI, body mass index; CCT, central corneal thickness; DBP, diastolic blood pressure; DM, diabetes mellitus; HbA1C, glycated haemoglobin; HDL, high-density lipoprotein; HsCRP, high-sensitivity C reactive protein; HsCRP, high-sensitivity C reactive protein; HT, hypertension; ILM, internal limiting membrane; IOP, intraocular pressure; LDL, low-density lipoprotein; logMAR, logarithm of the minimum angle of resolution; NFLP, nerve fibre layer plexure, ranging from ILM to outer limit of nerve fibre layer; ;SBP, systolic blood pressure; SE, spherical equivalent; SSI, Signal Strength Index; TG, triglyceride; WC, waist circumference.