Baseline demographic and clinical characteristics of the patients.
| Ophthalmic artery stenosis or occlusion group (N=17 eyes) | Control group (N=90 eyes) | P value | Total (N=107 eyes) | |
| Age at diagnosis (months) | ||||
| Mean(SD) | 22.29 (15.95) | 24.40 (18.02) | 0.55 | 24.07 (17.6) |
| Sex (%) | ||||
| Male | 7 (41.2) | 46 (51.1) | 0.60 | 53 (49.5) |
| Female | 10 (58.8) | 44 (48.9) | 0.99 | 54 (50.5) |
| IIRC stage (%) | ||||
| Group C | 0 (0.0) | 8 (8.9) | 0.61 | 8 (7.5) |
| Group D | 2 (11.8) | 27 (30.0) | 0.14 | 29 (32.2) |
| Group E | 15 (88.2) | 55 (61.1) | 0.17 | 70 (77.8) |
| OA diameter (mm), median (range) | ||||
| Total | 0.49 (0.22–0.67) | 0.66 (0.37–1.03) | 0.062 | 0.66 (0.22–1.03) |
| Angles between OA and ICA, median (range) | ||||
| Group C | / | 32.73 (18.89–75.86) | / | 32.73 (18.89–75.86) |
| Group D | 12.03 (11.59–12.47) | 34.63 (8.67–98.23) | 0.411 | 32.45 (8.68–98.23) |
| Group E | 30.11 (22.35–37.30) | 30.26 (7.48–91.13) | 0.443 | 30.70 (7.47–91.13) |
| Enucleation (%) | ||||
| Group C | 0 | 0 | / | 0 |
| Group D | 0 | 1 (3.7) | / | 1 (3.4) |
| Group E | 6 (40.0) | 30 (54.5) | 0.071 | 36 (51.4) |
| Number of IAC, median (IQR) | 3 (2–4) | 3 (2–4) | 0.084 | 3 (2–4) |
| Number of IAC (%) | ||||
| 7 | 1 (5.9) | 0 | 0.365 | 1 (0.9) |
| 6 | 1 (5.9) | 4 (4.4) | 5 (4.7) | |
| 5 | 0 | 3 (3.3) | 3 (2.8) | |
| 4 | 7 (41.2) | 36 (40.0) | 43 (40.2) | |
| 3 | 6 (35.3) | 19 (21.1) | 25 (23.4) | |
| 2 | 2 (11.8) | 14 (15.6) | 16 (15.0) | |
| 1 | 0 | 15 (16.7) | 15 (14.0) | |
| Difference of OA diameter between first IAC and final IAC, mean (SD) | 0.219 (0.087) | 0.123 (0.089) | 0.001 | 0.138 (0.09) |
| Difference of OA orifice diameter between first IAC and final IAC, mean (SD) | 0.143 (0.122) | 0.099 (0.114) | 0.001 | 0.106 (0.12) |
| Percentage of OA diameter differences, mean (SD) | 36.5% (0.206) | 17.0% (0.145) | 0.001 | 20.1% (0.171) |
| Percentage of OA diameter differences at ostial position, mean (SD) | 34.8% (0.168) | 19.3% (0.151) | 0.0001 | 21.8% (0.163) |
Percentage of ophthalmic artery (OA) diameter differences refers to the ratio of the diameter differences between first and last intra-arterial chemotherapy (IAC) to the OA diameter at first treatment; percentage of OA orifice diameter differences refers to the ratio of the diameter differences at ostial position between first and last IAC to the diameter of OA at ostial position at first treatment.
*Indicates significant value (p<0.05).
ICA, internal carotid artery.