Comparison of DIGIROP-Screen versus other existing ROP prediction models
Comparison model and time point | N/N Specificity (95% CI) (%) | N/N Sensitivity (95% CI) (%) | ||
DIGIROP-Screen | Comparison ROP model | DIGIROP-Screen | Comparison ROP model | |
DIGIROP-Screen (up to PNA 8 w) vs CHOP-ROP17 (up to PNA 8 w) | 278/571 48.7 (44.5 to 52.9) | 157/571 27.5 (23.9 to 31.4) | 26/26 100.0 (86.8 to 100.0) | 26/26 100.0 (86.8 to 100.0) |
DIGIROP-Screen (up to PNA 12 w) vs CHOP-ROP17 (up to PNA 12 w) | 362/569 63.6 (59.5 to 67.6) | 159/569 27.9 (24.3 to 31.8) | 26/26 100.0 (86.8 to 100.0) | 26/26 100.0 (86.8 to 100.0) |
DIGIROP-Screen (up to PMA 36 w) vs OMA-ROP18 (up to PMA 36 w) | 250/541 46.2 (41.9 to 50.5) | 206/541 38.1 (34.0 to 42.3) | 24/25 96.0 (79.6 to 99.9) | 24/25 96.0 (79.6 to 99.9) |
DIGIROP-Screen (up to WINROP risk flag or last measurement) vs WINROP12 | 256/568 45.1 (40.9 to 49.3) | 257/568 45.2 (41.1 to 49.4) | 25/26 96.2 (80.4 to 99.9) | 23/26 88.5 (69.8 to 97.6) |
DIGIROP-Screen (at birth) vs CO-ROP16 (at PNA 4 w) | 231/564 41.0 (36.9 to 45.1) | 54/564 9.6 (7.3 to 12.3) | 25/26 96.2 (80.4 to 99.9) | 25/26 96.2 (80.4 to 99.9) |
CHOP-ROP, Children’s Hospital of Philadelphia-ROP; CO-ROP, Colorado-ROP; OMA-ROP, Omaha ROP; PMA, postmenstrual age; PNA, postnatal age; ROP, retinopathy of prematurity; w, weeks; WINROP, weight, insulin-like growth factor 1, neonatal, ROP.