Table 3

Univariable analysis of recipient, donor and surgery parameters for developing early graft failure after DMEK surgery

	All consecutive performed DMEK (n=752)
	Early graft failure (n=85) (%)	OR	95% CI	P value
Recipient parameters
Age, years		1.03 (per 1 unit)	1.00 to 1.06	0.037
Sex		1.55	0.98 to 2.44	0.06
Male	14
Female	9
Baseline IOP, mm Hg		1.03 (per 1 unit)	0.96 to 1.10	0.43
Baseline CCT, µm		1.00 (per 1 unit)	1.00 to 1.01	0.43
Indication, FED		0.8	0.39 to 1.62	0.53
Yes	11
No	14
Indication, PBK		1.59	0.45 to 5.61	0.47
Yes	16
No	11
Indication, graft failure		1.24	0.47 to 3.27	0.66
Yes	14
No	11
Lens status, PPC		1.59	0.87 to 2.89	0.13
Yes	12
No	8
Ocular comorbidities, except cataract		0.81	0.41 to 1.63	0.56
Yes	10
No	12
Donor parameters
Age, years		0.98 (per 1 unit)	0.95 to 1.01	0.15
Sex		1.12	0.70 to 1.80	0.64
Male	12
Female	11
Graft diameter, mm
<8.5	20	–	–	–
8.5	8	0.37	0.21 to 0.64	<0.001
>8.5	24	1.25	0.58 to 2.74	0.57
ECD, cells/mm²		1.00 (per 1 unit)	1.00 to 1.00	0.65
Complicated graft preparation		2.15	0.70 to 6.62	0.17
Yes	21
No	11
Surgery parameters
Surgical complication		2.83	1.50 to 5.32	0.001
Yes	24
No	10
Diameter descemetorhexis, mm
<8.5	11	–	–	–
8.5	8	0.67	0.33 to 1.33	0.25
>8.5	15	1.41	0.76 to 2.61	0.27
Recipient donor sex mismatch		1.02	0.65 to 1.61	0.93
Yes	11
No	11
Surgery date after 2015		0.32	0.19 to 0.54	<0.001
Yes	9
No	24
Triple procedure		0.84	0.33 to 2.19	0.73
Yes	10
No	11
Phakic DMEK		0.33	0.08 to 1.40	0.08
Yes	4
No	12
PPC vs phakic DMEK		3.15	0.75 to 13.35	0.1
PPC vs triple		1.29	0.49 to 3.34	0.61
PPC and triple vs phakic DMEK		3.09	0.73 to 12.98	0.11
Eye undergoing surgery		0.78	0.49 to 1.23	0.28
Left	10
Right	13

CCT, central cornea thickness; DMEK, Descemet membrane endothelial keratoplasty; ECD, endothelial cell density; FED, Fuchs endothelial dystrophy; IOP, intraocular pressure; PBK, pseudophakic bullous keratopathy; PPC, pseudophakic, posterior chamber.