Endocrinological history of patients referred in EUGOGO centres between September and December 2019 and comparative data from the 2012 study
| 2019 | 2012 | P value | |||
| % | N | % | N | ||
| Thyroid disease | |||||
| Graves | 89.9 | 381/432 | 94.1 | 253/269 | 0.054 |
| Others (Hashimoto, primary hypothyroidism, no thyroid disease) | 10.1 | 43/432 | 5.9 | 16/269 | |
| Laboratory findings | |||||
| Elevated TRAb | 74.8 | 234/313 | 80.5 | 157/195 | 0.134 |
| fT3 | |||||
| Normal | 75.6 | 59/78 | 73.6 | 190/258 | 0.561 |
| High | 19.2 | 15/78 | 23.3 | 60/258 | |
| Low | 5.1 | 4/78 | 3.1 | 8/258 | |
| Thyrotropin | |||||
| Normal | 45.9 | 50/109 | 49.5 | 138/279 | 0.809 |
| High | 15.6 | 17/109 | 15.1 | 42/279 | |
| Low | 38.5 | 42/109 | 35.5 | 99/279 | |
| Comorbidites | |||||
| Glaucoma | 13.1 | 55/420 | 5.6 | 15/267 | 0.002 |
| Diabetes | 8.9 | 38/429 | 3.7 | 10/267 | 0.010 |
| Other concomitant diseases | 52.0 | 219/421 | 39.8 | 88/221 | 0.003 |
| Visible goitre | 13.1 | 55/421 | 16.9 | 45/267 | 0.169 |
| Dermopathy | 3.2 | 13/411 | 0.8 | 2/266 | 0.037 |
| Family history of autoimmune thyroid disease | 33.3 | 113/400 | 38.7 | 99/256 | 0.157 |
| Family history of other autoimmune disease | 9.5 | 36/380 | 7.2 | 18/251 | 0.312 |
| Any previous/current anti-thyroid treatments | |||||
| Anti-thyroid drugs (ATD) | 80.2 | 337/420 | 45.0 | 118/262 | <0.001 |
| Radioiodine | 15.1 | 63/417 | 17.9 | 47/262 | 0.330 |
| Thyroidectomy | 24.1 | 102/423 | 22.7 | 59/260 | 0.671 |
| Previous/current steroids | 15.1 | 63/416 | 4.1 | 11/269 | <0.001 |
| Oral | 28.6 | 18/63 | 0.0 | 0/11 | |
| Intravenous | 58.7 | 37/63 | 0.0 | 0/11 | |
| Not available | 12.7 | 8/63 | 100.0 | 11/11 | |
| Current medication | |||||
| Methimazole | 34.5 | 148/429 | 26.0 | 70/269 | 0.019 |
| Carbimazole | 12.0 | 51/424 | 17.8 | 48/269 | 0.033 |
| Propylthiouracil | 3.0 | 13/427 | 3.7 | 10/269 | 0.629 |
| Block and replace (any ATD plus T4) | 6.3 | 13/208 | 22.0 | 28/127 | <0.001 |
| T4 substitution (without ATD) | 33.1 | 143/432 | 39.4 | 106/269 | 0.090 |
| Selenium | 22.3 | 94/421 | 3.0 | 8/269 | <0.001 |
| Beta blocker | 18.7 | 79/422 | 10.0 | 27/269 | 0.002 |
EUGOGO, European Group On Graves’ Orbitopathy.