Demography and characteristics at presentation of neonatal-onset and infantile-onset PCG and normal ethnically matched controls
| S No | Baseline characteristics | Neonatal onset PCG (n=28 eyes of 14) | Infantile onset PCG (n=58 eyes of 29) | P value | Normal controls |
| 1 | Gender (M: F) | 4: 10 | 24: 5 | 4:11 | |
| 2 | Age at presentation | 10.2±5.5 days | 11.4±6.7 months | 27 .9±2.1 years | |
| 3 | Baseline IOP (mm Hg) | 20.7±4.9 | 23.0±9.9 | p=0.63 | 13.9±2.3 mm Hg |
| CYPIBI mutations (n=22) | 22.2±3.1 (n=12) | 23.5±7.5 (n=10) | p=0.33 | ||
| No CYP1B1 mutations (n=64) | 20.3±6.1 (n=16) | 20.8±9.9 (n=48) | p=0.49 | ||
| 4 | P value | p=0.97 | p=0.44 | ||
| 5 | Corneal clarity (grade) | 2.7±1.3 | 1.5±1.1 | p=0.002 | Grade 0 in all |
| CYPIBI mutations (n=22) | 2.8±0.9 (n=12) | 2.2±1.3 (n=10) | p=0.28 | ||
| No CYP1B1 mutations (n=64) | 2.1±1.3 (n=16) | 1.3±0.9 (n=48) | p=0.02 | ||
| 6 | P value | p=0.29 | p=0.02 | ||
| 7 | Corneal diameter (mm) | 12.1±1.1 | 13.2±1.1 | Not applicable in adults | |
| 8 | Axial length (mm) | 19.3±2.1 | 22.5±1.9 | ||
| Follow-up | |||||
| 1 | Number of surgical or laser procedures required | 3.6 | 2.5 | ||
| 2 | Outcome 1 year after surgery | Poor (n=11 | Poor (n=5) | p=0.002 | |
| Fair (n=13) | Fair (n=13) | ||||
| Good (n=4) | Good (n=40) | p<0.0001 | |||
IOP, intraocular pressure; PCG, primary congenital glaucoma.