Risk factors associated with treatment outcome: univariate Cox proportional hazard analysis
| Covariate | Univariate | ||
| HR | 95% CI | p Value | |
| Overall survival | |||
| Age (continuous; median 69.47 years) | 1.056 | 1.015 to 1.100 | 0.008 |
| Sex (dichotomous; female (n=46) vs male (n=55)) | 0.402 | 0.146 to 1.108 | 0.078 |
| Affected eye (dichotomous; right (n=45) vs left (n=56)) | 0.964 | 0.398 to 2.331 | 0.934 |
| Diagnosis (dichotomous; choroidal (n=90) vs ciliochoroidal (n=11)) | 1.465 | 0.487 to 4.410 | 0.497 |
| Gross tumour volume (continuous; median 0.42 cm3) | 2.650 | 1.556 to 4.512 | <0.001 |
| Tumour thickness (continuous; median 5.03 mm) | 1.197 | 1.072 to 1.336 | <0.001 |
| Largest basal diameter (continuous; median 10.00 mm) | 1.185 | 1.063 to 1.321 | 0.002 |
| Affected eye segments (dichotomous; >3 (n=44) vs 3 (n=57) affected segments) | 2.846 | 1.032 to 7.849 | 0.043 |
| Juxtapapillary tumour location (dichotomous; no (n=56) vs yes (n=45)) | 0.819 | 0.337 to 1.988 | 0.659 |
| Time between diagnosis and therapy (continuous; median 35.00 days) | 0.991 | 0.963 to 1.020 | 0.531 |
| Disease-specific survival | |||
| Age (continuous; median 69.47 years) | 1.055 | 0.990 to 1.125 | 0.098 |
| Sex (dichotomous; female (n=46) vs male (n=55)) | 0.732 | 0.175 to 3.063 | 0.669 |
| Affected eye (dichotomous; right (n=45) vs left (n=56)) | 1.254 | 0.313 to 5.019 | 0.749 |
| Diagnosis (dichotomous; choroidal (n=90) vs ciliochoroidal (n=11)) | 0.885 | 0.108 to 7.223 | 0.909 |
| Gross tumour volume (continuous; median 0.42 cm3) | 3.152 | 1.352 to 7.346 | 0.008 |
| Tumour thickness (continuous; median 5.03 mm) | 1.171 | 0.987 to 1.338 | 0.070 |
| Largest basal diameter (continuous; median 10.00 mm) | 1.123 | 0.948 to 1.329 | 0.178 |
| Affected eye segments (dichotomous; >3 (n=44) vs 3 (n=57) affected segments) | 0.966 | 0.241 to 3.867 | 0.961 |
| Juxtapapillary tumour location (dichotomous; no (n=56) vs yes (n=45)) | 0.338 | 0.068 to 1.693 | 0.187 |
| Time between diagnosis and therapy (continuous; median 35.00 days) | 1.004 | 0.979 to 1.030 | 0.739 |
| Local recurrence-free survival | |||
| Age (continuous; median 69.47 years) | 1.010 | 0.951 to 1.073 | 0.738 |
| Sex (dichotomous; female (n=46) vs male (n=55)) | 0.563 | 0.103 to 3.083 | 0.508 |
| Affected eye (dichotomous; right (n=45) vs left (n=56)) | 0.018 | 0.000 to 13.128 | 0.232 |
| Diagnosis (dichotomous; choroidal (n=90) vs ciliochoroidal (n=11)) | 15.108 | 2.764 to 82.587 | 0.002 |
| Gross tumour volume (continuous; median 0.42 cm3) | 5.911 | 2.161 to 16.163 | <0.001 |
| Tumour thickness (continuous; median 5.03 mm) | 1.303 | 1.061 to 1.600 | 0.012 |
| Largest basal diameter (continuous; median 10.00 mm) | 1.244 | 1.020 to 1.518 | 0.031 |
| Affected eye segments (dichotomous; >3 (n=44) vs 3 (n=57) affected segments) | 5.024 | 0.582 to 43.390 | 0.142 |
| Juxtapapillary tumour location (dichotomous; no (n=56) vs yes (n=45)) | 0.204 | 0.024 to 1.766 | 0.149 |
| Time between diagnosis and therapy (continuous; median 35.00 days) | 1.021 | 1.007 to 1.036 | 0.003 |
| Distant metastasis-free survival | |||
| Age (continuous; median 69.47 years) | 1.024 | 0.978 to 1.073 | 0.308 |
| Sex (dichotomous; female (n=46) vs male (n=55)) | 0.612 | 0.184 to 2.033 | 0.423 |
| Affected eye (dichotomous; right (n=45) vs left (n=56)) | 1.176 | 0.379 to 3.646 | 0.779 |
| Diagnosis (dichotomous; choroidal (n=90) vs ciliochoroidal (n=11)) | 2.320 | 0.627 to 8.577 | 0.207 |
| Gross tumour volume (continuous; median 0.42 cm3) | 3.052 | 1.505 to 6.191 | 0.002 |
| Tumour thickness (continuous; median 5.03 mm) | 1.182 | 1.029 to 1.357 | 0.018 |
| Largest basal diameter (continuous; median 10.00 mm) | 1.136 | 0.993 to 1.299 | 0.063 |
| Affected eye segments (dichotomous; >3 (n=44) vs 3 (n=57) affected segments) | 1.733 | 0.521 to 5.759 | 0.370 |
| Juxtapapillary tumour location (dichotomous; no (n=56) vs yes (n=45)) | 0.382 | 0.103 to 1.415 | 0.150 |
| Time between diagnosis and therapy (continuous; median 35.00 days) | 0.997 | 0.970 to 1.024 | 0.825 |
| Enucleation-free survival | |||
| Age (continuous; median 69.47 years) | 1.031 | 0.968 to 1.098 | 0.338 |
| Sex (dichotomous; female (n=46) vs male (n=55)) | 0.401 | 0.076 to 2.107 | 0.281 |
| Affected eye (dichotomous; right (n=45) vs left (n=56)) | 0.017 | 0.000 to 7.399 | 0.188 |
| Diagnosis (dichotomous; choroidal (n=90) vs ciliochoroidal (n=11)) | 7.693 | 1.550 to 38.193 | 0.013 |
| Gross tumour volume (continuous; median 0.42 cm3) | 5.763 | 2.130 to 15.590 | 0.001 |
| Tumour thickness (continuous; median 5.03 mm) | 1.192 | 0.988 to 1.437 | 0.066 |
| Largest basal diameter (continuous; median 10.00 mm) | 1.219 | 1.017 to 1.461 | 0.033 |
| Affected eye segments (dichotomous; >3 (n=44) vs 3 (n=57) affected segments) | 1.359 | 0.299 to 6.180 | 0.692 |
| Juxtapapillary tumour location (dichotomous; no (n=56) vs yes (n=45)) | 0.706 | 0.151 to 3.303 | 0.658 |
| Time between diagnosis and therapy (continuous; median 35.00 days) | 1.020 | 1.007 to 1.034 | 0.003 |
Bold values are significant (p value <0.05).
95% CI, 95% confidence interval; HR, hazard ratio; n, number of patients.