Comparison of the classification performance of HCP, OCT and HVF in a population of controls (n=172) and patients with glaucoma
| HCP | OCT | HVF | |
| All glaucoma (n=132) | |||
| AUC | 0.93 (0.90 to 0.96) | 0.98 (0.96 to 0.99)* | 0.94 (0.92 to 0.97)† |
| Sensitivity, % | 85.6 (78.4 to 91.1) | 97.0 (92.4 to 99.2) | 86.4 (79.3 to 91.7) |
| Specificity, % | 89.5 (84.0 to 93.7) | 91.3 (86.0 to 95.0) | 92.4 (87.4 to 95.9) |
| PPV, %‡ | 23.1 (16.2 to 31.9) | 29.0 (20.1 to 39.9) | 29.5 (19.8 to 41.5) |
| NPV, %‡ | 99.4 (99.1 to 99.6) | 99.9 (99.7 to 1) | 99.5 (99.2 to 99.7) |
| Accuracy, %‡ | 89.4 (85.4 to 92.6) | 91.5 (87.8 to 94.3) | 92.2 (88.6 to 95.0) |
| Early-moderate glaucoma (n=87) | |||
| AUC | 0.91 (0.87 to 0.95) | 0.97 (0.95 to 0.99)* | 0.91 (0.87 to 0.96)† |
| Sensitivity, % | 81.6 (71.9 to 89.1) | 95.4 (88.6 to 98.7) | 79.3 (69.3 to 87.3) |
| Specificity, % | 90.1 (84.6 to 94.1) | 92.4 (87.4 to 95.9) | 92.4 (87.4 to 95.9) |
| Severe glaucoma (n=45) | |||
| AUC | 0.98 (0.97 to 1) | 1 (1 to 1) | 1 (1 to 1) |
| Sensitivity, % | 95.6 (84.9 to 99.5) | 100 (92.1 to 100) | 100 (92.1 to 100) |
| Specificity, % | 94.2 (89.6 to 97.2) | 97.7 (94.2 to 99.4) | 100 (97.9 to 100) |
Data are represented as average (95% CI). The statistical pairwise comparison of AUCs was performed using DeLong’s method.
*p<0.05 between HCP and OCT, after Bonferroni correction.
†p<0.05 between HVF and OCT, after Bonferroni correction.
‡Values calculated at a disease prevalence of 3.54%.
AUC, area under the curve; HCP, handheld chromatic pupillometry; HVF, Humphrey Visual Field; NPV, negative predictive value; OCT, optical coherence tomography; PPV, positive predictive value.