Table 2

Univariable and multivariable COX proportional hazards regression analysis for the predictors of nodal metastasis

	Univariable		Multivariable
	HR (95% CI)	P value	HR (95% CI)	P value
Age, years	0.99 (0.97 to 1.02)	0.454
Sex (female vs male)	1.40 (0.73 to 2.68)	0.309
Laterality (left vs right)	1.16 (0.62 to 2.16)	0.648
Diabetes	0.61 (0.15 to 2.55)	0.502
History of diuretic use	0.74 (0.23 to 2.39)	0.613
HBV, HBsAg (+)	0.05 (0 to 29.44)	0.351
Diagnostic delay, months	1.00 (0.99 to 1.01)	0.550
Upper lid	0.97 (0.52 to 1.82)	0.926
Lower lid	1.08 (0.58 to 2.02)	0.814
Both upper lid and lower lid	2.21 (0.68 to 7.18)	0.186
Medial canthus	3.26 (1.50 to 7.08)	0.003*	1.09 (0.35 to 3.44)	0.878
Initial diagnosis (others vs sebaceous carcinoma)	0.76 (0.38 to 1.53)	0.442
Tumour presentation pattern (diffuse vs nodule)	4.16 (1.73 to 10.00)	0.001*	4.34 (1.75 to 10.76)	0.002*
Greatest basal diameter, mm	1.05 (1.01 to 1.08)	0.008*	1.02 (0.99 to 1.06)	0.220
Orbital invasion at presentation	3.98 (1.83 to 8.65)	<0.001*	3.22 (1.42 to 7.33)	0.005*
Pagetoid spread	1.02 (0.52 to 2.01)	0.953
Multicentric origin	1.88 (0.83 to 4.25)	0.130
PNI	6.51 (2.30 to 18.42)	<0.001*	3.24 (1.11 to 9.49)	0.032*
Perivascular invasion	2.27 (0.31 to 16.57)	0.419
Muscle infiltration	1.76 (0.86 to 3.61)	0.121
Ki-67 percentage	1.04 (1.02 to 1.05)	<0.001*	1.03 (1.01 to 1.05)	<0.001*
Histological differentiation
Moderate versus well	1.28 (0.45 to 3.66)	0.650
Poor versus well	2.67 (0.84 to 8.53)	0.097
With positive surgical margin	1.01 (0.42 to 2.41)	0.991
Local recurrence	1.23 (0.58 to 2.58)	0.590
Initial treatment
Wide local excision versus frozen margin control	2.05 (0.87 to 4.87)	0.103
Orbital exenteration versus frozen margin control	10.29 (3.44 to 30.75)	<0.001*
Wide local excision versus orbital exenteration	0.20 (0.08 to 0.49)	<0.001*

*Statistically signiﬁcant.
HBV, hepatitis B virus; PNI, perineural invasion.